Calpastatin Activators
Calpastatin activators are a group of chemical compounds that interact with a specific protein known as calpastatin, which plays a pivotal role in regulating the activity of enzymes called calpains. Calpains are a family of calcium-dependent cysteine proteases that are involved in various cellular processes, including cell signaling, cytoskeletal remodeling, and protein degradation. Calpastatin, on the other hand, is an endogenous inhibitor that tightly controls the activity of calpains by binding to them and preventing their proteolytic actions. Calpastatin activators, as the name suggests, are molecules that modulate the function of calpastatin, leading to altered regulation of calpain activity within cells.
These activators typically work by enhancing the binding affinity of calpastatin to calpains or by stabilizing the calpastatin protein itself. By doing so, they can either increase or decrease the inhibition of calpain enzymes, depending on their specific mechanism of action. This fine-tuned control of calpain activity is crucial for maintaining cellular homeostasis and ensuring that calpains are active only when necessary. Researchers have been exploring the ability of calpastatin activators in various biological contexts to better understand the intricate regulatory mechanisms of calpains and their impact on cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects gene expression and may upregulate calpastatin as part of cellular differentiation pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoids like dexamethasone can influence protein synthesis and may enhance calpastatin expression in response to stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol found in green tea has been shown to modulate protein expression and could potentially increase calpastatin levels as part of a protective cellular response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may exert its effects by modulating signal transduction pathways, which could include the upregulation of calpastatin expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a phytoalexin, resveratrol can alter gene expression, which may encompass the induction of calpastatin for cellular protection. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Oxidative stress induced by hydrogen peroxide can lead to adaptive cellular responses, including the upregulation of protective proteins like calpastatin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium impacts glycogen synthase kinase-3 (GSK-3) activity, which can influence various proteins’ expression, potentially including calpastatin. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can affect chromatin structure and gene expression, potentially enhancing calpastatin levels. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Exposure to lead compounds can induce a range of cellular responses, which may include the upregulation of calpastatin as a stress response. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride exposure induces stress proteins, and it is plausible that this could extend to calpastatin as part of a protective mechanism. | ||||||