Calpain 7 Antibody (F-10): sc-515534

Calpain 7 Antibody (F-10) is a mouse monoclonal IgG2a antibody that detects Calpain 7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Calpain 7 is a unique member of the calpain family, characterized by 813 amino acid residues and a distinct structure that includes a long N-terminal domain and a PalB homologous domain flanking the protease domain. This atypical calpain lacks domain IV, which is crucial for dimerization with the 30 kDa regulatory subunit, making Calpain 7 functionally different from other calpains. Calpain 7 is predominantly localized in the cytoplasm and nucleus, with activated forms found exclusively in the nucleus, highlighting potential roles in nuclear processes. Calpain 7 exhibits a ubiquitous tissue distribution but shows particularly high expression levels in the brain, suggesting involvement in neurological functions. Research indicates that upregulation of Calpain 7 in striatal or cortical tissues of Huntington′s Disease knock-in mice may link Calpain 7 to the pathogenesis of the disease, underscoring significance in neurodegenerative disorders. anti-Calpain 7 antibody (F-10) is an essential tool for researchers investigating the role of this protease in various biological processes and disease mechanisms.

The preferred Calpain 7 antibody is Calpain 7 Antibody (B-7): sc-137227.