Calpain 7 Antibody (D-2): sc-137156
- Calpain 7 Antibody (D-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Calpain 7 of human origin
- Anti-Calpain 7 Antibody (D-2) is recommended for detection of Calpain 7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Calpain 7 Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Calpain 7 Antibody (D-2) for WB applications. These reagents are now offered in bundles with Calpain 7 Antibody (D-2) (see ordering information below).
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SEE ALSO...
Calpain 7 Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Calpain 7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Calpain 7 (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calpain 7, also known as PalBH, is a member of the Non-EF-hand subfamily of calpains and is characterized by a unique structure, including a long N-terminal domain and a PalB homologous domain flanking the calpain protease domain. This atypical calpain, consisting of 813 amino acid residues, exhibits only 26-35% shared identity with other calpain family members, primarily within the protease domain. The distinct structure lacks domain IV, preventing dimer formation with the 30 kDa regulatory subunit, which is crucial for typical calpain activation. Calpain 7 is predominantly expressed in the brain and localizes in both cytoplasm and nucleus, with activated forms found exclusively in the nucleus. Upregulation of Calpain 7 in striatal or cortical tissue of Huntington′s Disease knock-in mice suggests a potential role in disease onset, highlighting the importance of understanding cellular pathway functions and interactions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 7 Antibody (D-2) | sc-137156 | 200 µg/ml | $316.00 | |||
Calpain 7 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-527124 | 200 µg Ab; 10 µg BP | $354.00 | |||
Calpain 7 Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-532497 | 200 µg Ab; 20 µg BP | $354.00 | |||
Calpain 7 Antibody (D-2) AC | sc-137156 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Calpain 7 Antibody (D-2) HRP | sc-137156 HRP | 200 µg/ml | $316.00 | |||
Calpain 7 Antibody (D-2) FITC | sc-137156 FITC | 200 µg/ml | $330.00 | |||
Calpain 7 Antibody (D-2) PE | sc-137156 PE | 200 µg/ml | $343.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 488 | sc-137156 AF488 | 200 µg/ml | $357.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 546 | sc-137156 AF546 | 200 µg/ml | $357.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 594 | sc-137156 AF594 | 200 µg/ml | $357.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 647 | sc-137156 AF647 | 200 µg/ml | $357.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 680 | sc-137156 AF680 | 200 µg/ml | $357.00 | |||
Calpain 7 Antibody (D-2) Alexa Fluor® 790 | sc-137156 AF790 | 200 µg/ml | $357.00 |