Calpain 1 Antibody (6C-12): sc-32327
- Calpain 1 Antibody (6C-12) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against calpain 1 large (catalytic) subunit complexed to the small regulatory subunit from human erythrocytes
- recommended for detection of Calpain 1 of mouse, rat and human origin by WB, IP and IF
- See Calpain 1 (D-11): sc-271313 for Calpain 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Calpain 1 Antibody (6C-12) for WB applications. These reagents are now offered in bundles with Calpain 1 Antibody (6C-12) (see ordering information below).
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SEE ALSO...
Calpain 1 Antibody (6C-12) is a mouse monoclonal IgG1 antibody that detects Calpain 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Calpain 1, also known as µ-calpain, is an intracellular calcium-dependent protease that plays a crucial role in various cellular processes by cleaving cytoskeletal and submembranous proteins. Anti-Calpain 1 antibody (6C-12) recognizes a protein essential for mediating specific calcium-dependent functions, including cell fusion, mitosis, and meiosis, which are vital for normal cellular activities and development. The structure of Calpain 1 is characterized by its heterodimeric composition, consisting of a small regulatory subunit and a large catalytic subunit, which allows for precise regulation of proteolytic activity. Calpain 1′s regulation is further influenced by calpastatin, a specific inhibitor that modulates activity and membrane binding, highlighting the importance of post-translational modifications in controlling function. Notably, Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain, suggesting involvement in neuroinflammatory processes. Additionally, Calpain 1 is critical in spermatogenesis and the acrosome reaction, underscoring significance in reproductive biology. Calpain 1 monoclonal antibody (6C-12) serves as an invaluable tool for researchers studying cellular dynamics and signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 1 Antibody (6C-12) | sc-32327 | 200 µg/ml | $316.00 | |||
Calpain 1 Antibody (6C-12): m-IgG Fc BP-HRP Bundle | sc-536740 | 200 µg Ab; 10 µg BP | $354.00 | |||
Calpain 1 Antibody (6C-12): m-IgGκ BP-HRP Bundle | sc-533901 | 200 µg Ab; 40 µg BP | $354.00 |