cadherin-23 Antibody (H-7): sc-166066
- cadherin-23 Antibody (H-7) is a mouse monoclonal IgG2a κ cadherin-23 antibody provided at 200 µg/ml
- raised against amino acids 151-450 mapping within an extracellular domain of cadherin-23 of human origin
- cadherin-23 Antibody (H-7) is recommended for detection of cadherin-23 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-cadherin-23 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cadherin-23 Antibody (H-7) for WB applications. These reagents are now offered in bundles with cadherin-23 Antibody (H-7) (see ordering information below).
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cadherin-23 Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects cadherin-23 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-cadherin-23 antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. cadherin-23 plays a crucial role in cell adhesion and is essential for proper functioning of sensory cells in the inner ear and retina. Localization in the inner ear is particularly important, as cadherin-23 is found at the tips of hair cells where adherens junctions form that are vital for mechanotransduction—the process by which sound vibrations convert into electrical signals. Mutations in cadherin-23 can disrupt these junctions, leading to inherited disorders such as Usher syndrome type 1D (USH1D), characterized by congenital sensorineural hearing loss, vestibular dysfunction, and visual impairment due to early onset of retinitis pigmentosa. cadherin-23 interacts with myosin VIIIa and harmonin, forming a functional network critical during hair cell differentiation. Various cadherin-23 splice variants further complicate phenotypic expression of associated diseases, highlighting cadherin-23′s importance in both cellular structure and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cadherin-23 Antibody (H-7) References:
- Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. | Bolz, H., et al. 2001. Nat Genet. 27: 108-12. PMID: 11138009
- Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). | Di Palma, F., et al. 2001. Gene. 281: 31-41. PMID: 11750125
- The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. | Siemens, J., et al. 2002. Proc Natl Acad Sci U S A. 99: 14946-51. PMID: 12407180
- Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. | Boëda, B., et al. 2002. EMBO J. 21: 6689-99. PMID: 12485990
- Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family. | de Brouwer, AP., et al. 2003. Hum Genet. 112: 156-63. PMID: 12522556
- Office-based arthroscopy. | Arnold, WJ. 1992. Bull Rheum Dis. 41: 3-6. PMID: 1291027
- Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells. | Reiners, J., et al. 2003. Invest Ophthalmol Vis Sci. 44: 5006-15. PMID: 14578428
- Cadherin 23 is a component of the tip link in hair-cell stereocilia. | Siemens, J., et al. 2004. Nature. 428: 950-5. PMID: 15057245
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cadherin-23 Antibody (H-7) | sc-166066 | 200 µg/ml | $316.00 | |||
cadherin-23 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-528901 | 200 µg Ab; 10 µg BP | $354.00 | |||
cadherin-23 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-521500 | 200 µg Ab, 40 µg BP | $354.00 | |||
cadherin-23 Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-547202 | 200 µg Ab; 10 µg BP | $354.00 | |||
cadherin-23 Antibody (H-7) AC | sc-166066 AC | 500 µg/ml, 25% agarose | $416.00 | |||
cadherin-23 Antibody (H-7) HRP | sc-166066 HRP | 200 µg/ml | $316.00 | |||
cadherin-23 Antibody (H-7) FITC | sc-166066 FITC | 200 µg/ml | $330.00 | |||
cadherin-23 Antibody (H-7) PE | sc-166066 PE | 200 µg/ml | $343.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 488 | sc-166066 AF488 | 200 µg/ml | $357.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 546 | sc-166066 AF546 | 200 µg/ml | $357.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 594 | sc-166066 AF594 | 200 µg/ml | $357.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 647 | sc-166066 AF647 | 200 µg/ml | $357.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 680 | sc-166066 AF680 | 200 µg/ml | $357.00 | |||
cadherin-23 Antibody (H-7) Alexa Fluor® 790 | sc-166066 AF790 | 200 µg/ml | $357.00 |