CacyBP Antibody (H-1): sc-166455
- CacyBP Antibody (H-1) is a mouse monoclonal IgG2b κ CacyBP antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-228 representing full length CacyBP of human origin
- CacyBP Antibody (H-1) is recommended for detection of CacyBP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CacyBP Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CacyBP Antibody (H-1) for WB applications. These reagents are now offered in bundles with CacyBP Antibody (H-1) (see ordering information below).
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CacyBP Antibody (H-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects CacyBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CacyBP antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CacyBP, or Calcyclin-binding protein, is a 228 amino acid protein encoded by the human gene CACYBP, primarily located in the nucleus. This protein contains one calcium-binding CS domain and one SGS domain, which are crucial for its function in calcium-dependent ubiquitination processes. The ability of CacyBP to interact with calcium ions is significant as CacyBP modulates the ubiquitin-proteasome pathway, facilitating the degradation of target proteins, including β-catenin. This interaction is particularly important in the context of cellular signaling and regulation, as β-catenin plays a vital role in the Wnt signaling pathway, which is implicated in cell growth and differentiation. By influencing β-catenin levels, CacyBP is thought to act as a potential inhibitor of cell growth and invasion in gastric cancer, highlighting CacyBP′s importance in cancer biology and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CacyBP Antibody (H-1) References:
- Differential gene expression in peripheral blood lymphocytes of cancer patients treated with whole body hyperthermia and chemotherapy: a pilot study. | Hildebrandt, B., et al. 2006. Int J Hyperthermia. 22: 625-35. PMID: 17390994
- Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. | Sun, S., et al. 2007. Biochem Biophys Res Commun. 356: 864-71. PMID: 17400182
- Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin. | Mei, Y., et al. 2007. Oncogene. 26: 6319-31. PMID: 17420721
- Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. | Herington, JL., et al. 2007. J Histochem Cytochem. 55: 963-74. PMID: 17533218
- Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein. | Liang, J., et al. 2007. Biochem Cell Biol. 85: 375-83. PMID: 17612632
- CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies. | Schneider, G., et al. 2007. Biochim Biophys Acta. 1773: 1628-36. PMID: 17916393
- Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. | Ning, X., et al. 2007. Mol Cancer Res. 5: 1254-62. PMID: 18171983
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CacyBP Antibody (H-1) | sc-166455 | 200 µg/ml | $322.00 | |||
CacyBP Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-521617 | 200 µg Ab, 40 µg BP | $361.00 | |||
CacyBP Antibody (H-1): m-IgG2b BP-HRP Bundle | sc-548941 | 200 µg Ab; 10 µg BP | $361.00 | |||
CacyBP Antibody (H-1) AC | sc-166455 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CacyBP Antibody (H-1) HRP | sc-166455 HRP | 200 µg/ml | $322.00 | |||
CacyBP Antibody (H-1) FITC | sc-166455 FITC | 200 µg/ml | $336.00 | |||
CacyBP Antibody (H-1) PE | sc-166455 PE | 200 µg/ml | $349.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 488 | sc-166455 AF488 | 200 µg/ml | $364.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 546 | sc-166455 AF546 | 200 µg/ml | $364.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 594 | sc-166455 AF594 | 200 µg/ml | $364.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 647 | sc-166455 AF647 | 200 µg/ml | $364.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 680 | sc-166455 AF680 | 200 µg/ml | $364.00 | |||
CacyBP Antibody (H-1) Alexa Fluor® 790 | sc-166455 AF790 | 200 µg/ml | $364.00 |