CacyBP Antibody (D-8): sc-166195

CacyBP Antibody (D-8) is a mouse monoclonal IgG2a antibody that detects CacyBP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CacyBP, or Calcyclin-binding protein, is a 228 amino acid protein encoded by the human gene CACYBP, primarily localized in the nucleus, where CacyBP plays a crucial role in calcium-dependent ubiquitination and the subsequent proteasomal degradation of target proteins. This nuclear localization enables CacyBP to effectively participate in protein turnover regulation within the cell, particularly in cellular responses to calcium signaling. By acting as a molecular bridge in ubiquitin E3 complexes, CacyBP facilitates the ubiquitin-mediated degradation of key proteins, including β-catenin, which maintains cellular homeostasis and regulates growth. Furthermore, CacyBP inhibits cell growth and invasion in gastric cancer by modulating β-catenin protein expression and transcriptional activation of TCF/LEF, highlighting CacyBP′s potential as a therapeutic target in cancer treatment. Anti-CacyBP antibody (D-8) serves as an essential tool for researchers investigating the roles of CacyBP in various biological processes and disease states.

The preferred CacyBP antibody is CacyBP Antibody (H-1): sc-166455.