CacyBP Antibody (A-10): sc-166163

CacyBP Antibody (A-10) is a mouse monoclonal IgG1 antibody that detects CacyBP in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CacyBP, or Calcyclin-binding protein, is a 228 amino acid protein encoded by the human gene CACYBP, primarily localized in the nucleus where CacyBP plays a crucial role in calcium-dependent ubiquitination and the subsequent proteosomal degradation of target proteins. CacyBP contains one CS domain and one SGS domain, which are essential for CacyBP′s function as a molecular bridge in ubiquitin E3 complexes. Notably, CacyBP is involved in the ubiquitin-mediated degradation of β-catenin, a key regulator of cell growth and proliferation. By modulating β-catenin levels, CacyBP acts as a potential inhibitor of cell growth and invasion in gastric cancer, highlighting CacyBP′s importance in cancer biology and therapeutic strategies. Anti-CacyBP antibody (A-10) serves as an invaluable tool for researchers studying the intricate mechanisms of protein degradation and implications in various diseases.

The preferred CacyBP antibody is CacyBP Antibody (H-1): sc-166455.