Cactin Antibody (D-10): sc-515391
- Cactin Antibody (D-10) is a mouse monoclonal IgG1 κ Cactin antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 268-291 within an internal region of Cactin of human origin
- Cactin Antibody (D-10) is recommended for detection of Cactin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Cactin Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cactin Antibody (D-10) for WB applications. These reagents are now offered in bundles with Cactin Antibody (D-10) (see ordering information below).
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SEE ALSO...
Cactin Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cactin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cactin (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cactin, also known as fSAPc, NY-REN-24, or C19orf29, is a 758 amino acid nuclear protein that plays a crucial role in regulating innate immune responses and is involved in early embryonic development and pre-mRNA splicing. Notably, Cactin acts as a negative regulator of Toll-like receptor and interferon-regulatory factor signaling pathways, which are essential for immune response. In response to endogenous pro-inflammatory stimuli, Cactin modulates transcriptional activation of NFκB genes, thereby influencing inflammation and immune regulation. The gene encoding Cactin is located on human chromosome 19p13.3 and mouse chromosome 10 C1, and may be associated with renal-cell carcinoma in patients. Additionally, Cactin exists as two alternatively spliced isoforms, which may have distinct functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cactin Antibody (D-10) References:
- Antigens recognized by autologous antibody in patients with renal-cell carcinoma. | Scanlan, MJ., et al. 1999. Int J Cancer. 83: 456-64. PMID: 10508479
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. | Jurica, MS., et al. 2002. RNA. 8: 426-39. PMID: 11991638
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | Talmud, PJ., et al. 2009. Am J Hum Genet. 85: 628-42. PMID: 19913121
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | Bailey, SD., et al. 2010. Diabetes Care. 33: 2250-3. PMID: 20628086
- Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. | Atzei, P., et al. 2010. J Biol Chem. 285: 36804-17. PMID: 20829348
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cactin Antibody (D-10) | sc-515391 | 200 µg/ml | $322.00 | |||
Cactin Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-531351 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cactin Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-525019 | 200 µg Ab, 40 µg BP | $361.00 | |||
Cactin Antibody (D-10): m-IgG1 BP-HRP Bundle | sc-544500 | 200 µg Ab; 20 µg BP | $361.00 | |||
Cactin Antibody (D-10) AC | sc-515391 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cactin Antibody (D-10) HRP | sc-515391 HRP | 200 µg/ml | $322.00 | |||
Cactin Antibody (D-10) FITC | sc-515391 FITC | 200 µg/ml | $336.00 | |||
Cactin Antibody (D-10) PE | sc-515391 PE | 200 µg/ml | $349.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 488 | sc-515391 AF488 | 200 µg/ml | $364.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 546 | sc-515391 AF546 | 200 µg/ml | $364.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 594 | sc-515391 AF594 | 200 µg/ml | $364.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 647 | sc-515391 AF647 | 200 µg/ml | $364.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 680 | sc-515391 AF680 | 200 µg/ml | $364.00 | |||
Cactin Antibody (D-10) Alexa Fluor® 790 | sc-515391 AF790 | 200 µg/ml | $364.00 | |||
Cactin (D-10) Neutralizing Peptide | sc-515391 P | 100 µg/0.5 ml | $69.00 |