CaBP4 Antibody (D-6): sc-271885

CaBP4 Antibody (D-6) is a mouse monoclonal IgA kappa light chain antibody that detects CaBP4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CaBP4 Antibody (D-6) is available as anti-CaBP4 antibody (D-6) without conjugation. Calcium binding protein 4 (CaBP4) plays a vital role in the retina, where CaBP4 is primarily localized in photoreceptor cells, specifically in the outer segments of rods and cones. This localization enables CaBP4 to effectively modulate calcium signaling in response to light, which is essential for visual transduction. Through calcium ion binding, CaBP4 influences the activity of various calcium-dependent enzymes and signaling pathways, thereby contributing to phototransduction regulation and maintaining photoreceptor cell health. CaBP4′s interaction with other proteins in the calcium binding protein family further underscores CaBP4′s importance in cellular signaling processes, particularly in vision.

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CaBP4 Antibody (D-6) References:

1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.  |  Haeseleer, F., et al. 2000. J Biol Chem. 275: 1247-60. PMID: 10625670
2. Different sorting of Lys-Asp-Glu-Leu proteins in rat liver.  |  Peter, F., et al. 1992. J Biol Chem. 267: 10631-7. PMID: 1316906
3. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function.  |  Haeseleer, F., et al. 2004. Nat Neurosci. 7: 1079-87. PMID: 15452577
4. A critical role of CaBP4 in the cone synapse.  |  Maeda, T., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4320-7. PMID: 16249514
5. Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness.  |  Zeitz, C., et al. 2006. Am J Hum Genet. 79: 657-67. PMID: 16960802
6. Phosphorylation of the Ca2+-binding protein CaBP4 by protein kinase C zeta in photoreceptors.  |  Lee, A., et al. 2007. J Neurosci. 27: 12743-54. PMID: 18003854
7. Interaction and colocalization of CaBP4 and Unc119 (MRG4) in photoreceptors.  |  Haeseleer, F. 2008. Invest Ophthalmol Vis Sci. 49: 2366-75. PMID: 18296658
8. A novel homozygous nonsense mutation in CABP4 causes congenital cone-rod synaptic disorder.  |  Littink, KW., et al. 2009. Invest Ophthalmol Vis Sci. 50: 2344-50. PMID: 19074807
9. Phosphorylation of CaBP1 and CaBP2 by protein kinase CK2.  |  Janson, IM., et al. 1997. J Biochem. 121: 112-7. PMID: 9058200

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaBP4 Antibody (D-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CaBP4 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaBP4 Antibody (D-6) Specifications

Alternate Product Name: CaBP4

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 2-21

Epitope Target: CaBP4

Epitope Species: mouse

Product Reactivity/Detection: CaBP4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CaBP4 Antibody (D-6): P: Blocking Peptide

The preferred CaBP1 antibody is CaBP1 Antibody (A-4): sc-365522.