CA XIV Antibody (A-4): sc-166438
- CA XIV Antibody (A-4) is a mouse monoclonal IgG1 κ CA XIV antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 21-48 near the N-terminus of CA XIV of human origin
- CA XIV Antibody (A-4) is recommended for detection of CA XIV of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- Anti-CA XIV Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CA XIV Antibody (A-4) for WB applications. These reagents are now offered in bundles with CA XIV Antibody (A-4) (see ordering information below).
CA XIV Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects CA XIV protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CA XIV antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CA XIV (A-4) antibody recognizes carbonic anhydrase XIV, a transmembrane enzyme that plays a crucial role in regulating pH and bicarbonate levels in tissues, which is vital for numerous physiological processes such as respiration and acid-base balance. CA XIV (A-4) monoclonal antibody targets a protein predominantly located in the brain and involved in cerebrospinal fluid formation, highlighting its importance in maintaining central nervous system homeostasis. CA XIV expression extends to various other tissues, including the kidney, where CA XIV contributes to bicarbonate reabsorption, further emphasizing its role in maintaining acid-base equilibrium. CA XIV′s unique expression pattern, in contrast to other carbonic anhydrases, suggests specialized functions in different tissues, making CA XIV a significant target for research in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CA XIV Antibody (A-4) References:
- Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. | Fujikawa-Adachi, K., et al. 1999. Genomics. 61: 74-81. PMID: 10512682
- Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. | Okuyama, T., et al. 1992. Proc Natl Acad Sci U S A. 89: 1315-9. PMID: 1311094
- Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene. | Venta, PJ., et al. 1991. Am J Hum Genet. 49: 1082-90. PMID: 1928091
- Human carbonic anhydrases and carbonic anhydrase deficiencies. | Sly, WS. and Hu, PY. 1995. Annu Rev Biochem. 64: 375-401. PMID: 7574487
- Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. | Ivanov, SV., et al. 1998. Proc Natl Acad Sci U S A. 95: 12596-601. PMID: 9770531
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA XIV Antibody (A-4) | sc-166438 | 200 µg/ml | $322.00 | |||
CA XIV Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-528968 | 200 µg Ab; 10 µg BP | $361.00 | |||
CA XIV Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-521609 | 200 µg Ab, 40 µg BP | $361.00 | |||
CA XIV Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-543244 | 200 µg Ab; 20 µg BP | $361.00 | |||
CA XIV Antibody (A-4) AC | sc-166438 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CA XIV Antibody (A-4) HRP | sc-166438 HRP | 200 µg/ml | $322.00 | |||
CA XIV Antibody (A-4) FITC | sc-166438 FITC | 200 µg/ml | $336.00 | |||
CA XIV Antibody (A-4) PE | sc-166438 PE | 200 µg/ml | $349.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 488 | sc-166438 AF488 | 200 µg/ml | $364.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 546 | sc-166438 AF546 | 200 µg/ml | $364.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 594 | sc-166438 AF594 | 200 µg/ml | $364.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 647 | sc-166438 AF647 | 200 µg/ml | $364.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 680 | sc-166438 AF680 | 200 µg/ml | $364.00 | |||
CA XIV Antibody (A-4) Alexa Fluor® 790 | sc-166438 AF790 | 200 µg/ml | $364.00 | |||
CA XIV (A-4) Neutralizing Peptide | sc-166438 P | 100 µg/0.5 ml | $69.00 |