CA IV Antibody (G-11): sc-74527
- CA IV Antibody (G-11) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-50 of CA IV of mouse origin
- recommended for detection of CA IV of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CA IV Antibody (G-11) for WB applications. This reagent is now offered in a bundle with CA IV Antibody (G-11) (see ordering information below).
CA IV Antibody (G-11) is a mouse monoclonal IgG2b antibody that detects carbonic anhydrase IV (CA IV) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CA IV is a glycosylphosphatidylinositol-anchored protein located on the outer surface of the plasma membrane, primarily found on the plasma face of microcapillaries and in the choriocapillaris of the human eye. This strategic localization allows CA IV to effectively catalyze the hydration-dehydration of carbon dioxide and bicarbonate, playing a vital role in renal acidification and the regulation of interstitial pH transients in the brain. CA IV′s activity is essential for maintaining acid-base balance and facilitating various physiological processes, including respiration and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Disruption in CA IV targeting can lead to impaired bicarbonate secretion, which is associated with dysfunction in cystic fibrosis cells, highlighting CA IV′s importance in both health and disease. Anti-CA IV antibody (G-11) serves as an invaluable tool for researchers studying the diverse roles of carbonic anhydrases in different tissues and their implications in various pathophysiological conditions.
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CA IV Antibody (G-11) References:
- Expression of carbonic anhydrase IV in mouse placenta. | Rosen, O., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 280: R365-75. PMID: 11208563
- Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. | Shah, GN., et al. 2005. Proc Natl Acad Sci U S A. 102: 16771-6. PMID: 16260723
- Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes. | Svichar, N., et al. 2006. Glia. 53: 241-7. PMID: 16265666
- Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm. | Wandernoth, PM., et al. 2010. PLoS One. 5: e15061. PMID: 21124840
- GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. | Schneider, HP., et al. 2013. Proc Natl Acad Sci U S A. 110: 1494-9. PMID: 23297198
- Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70. | Forero-Quintero, LS., et al. 2019. J Biol Chem. 294: 593-607. PMID: 30446621
- Carbonic anhydrase IV inhibits cell proliferation in gastric cancer by regulating the cell cycle. | Wang, B., et al. 2020. Oncol Lett. 20: 4. PMID: 32774478
- Carbonic Anhydrase IV Deficiency Causes Intrauterine Embryonic Loss in Mice. | Schumann, S., et al. 2025. Cells Tissues Organs. 1-11. PMID: 39908001
- Location of a membrane-bound carbonic anhydrase isoenzyme (CA IV) in the human male reproductive tract. | Parkkila, S., et al. 1993. J Histochem Cytochem. 41: 751-7. PMID: 8468457
- Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization. | Fleming, RE., et al. 1995. J Clin Invest. 96: 2907-13. PMID: 8675662
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA IV Antibody (G-11) | sc-74527 | 200 µg/ml | $322.00 | |||
CA IV Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-551971 | 200 µg Ab; 10 µg BP | $361.00 |