C5a Antibody (2952): sc-52634
- C5a Antibody (2952) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against C5a of human origin
- recommended for detection of a neo-epitope (des-Arg) on C5a that is formed upon cleavage of C5 into C5a and C5b of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for C5a Antibody (2952). This work is in progress.
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C5a Antibody (2952) is a mouse monoclonal IgG1 antibody that detects C5a in human samples through western blotting (WB). C5a, a potent anaphylatoxin, plays a critical role in the complement system, which is essential for immune defense against pathogens. Upon complement activation, C5a is released and binds to its specific G protein-coupled receptor, C5aR, found on various immune cells, including myeloid leukocytes. This interaction triggers a cascade of proinflammatory responses, such as cellular degranulation, smooth muscle contraction, and the release of cytokines, which are vital for orchestrating an effective immune response. The importance of C5a extends beyond its immediate effects; anti-C5a antibody (2952) is also useful in studying various pathophysiological conditions, including asthma and bacterial meningitis, where elevated levels of C5a correlate with disease severity. The C5 precursor undergoes a critical processing step where four basic residues are cleaved, resulting in the formation of the C5a and C5b chains linked by a disulfide bond. This post-translational modification is crucial as it activates C5, allowing for the release of C5a, which subsequently enhances the inflammatory response. C5a monoclonal antibody (2952) is an invaluable tool for researchers studying the complement system and its implications in immune-related diseases.
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C5a Antibody (2952) References:
- Complement component 5a receptor oligomerization and homologous receptor down-regulation. | Rabiet, MJ., et al. 2008. J Biol Chem. 283: 31038-46. PMID: 18772131
- Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. | Pavlovski, D., et al. 2012. FASEB J. 26: 3680-90. PMID: 22651932
- Role of C5a-C5aR axis in the development of atherosclerosis. | An, G., et al. 2014. Sci China Life Sci. 57: 790-4. PMID: 25104451
- CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. | Vaivoda, R., et al. 2015. J Immunol Res. 2015: 250456. PMID: 26613087
- Role of complement C5a and histones in septic cardiomyopathy. | Fattahi, F., et al. 2018. Mol Immunol. 102: 32-41. PMID: 29914696
- Emerging Insights into the Structure and Function of Complement C5a Receptors. | Pandey, S., et al. 2020. Trends Biochem Sci. 45: 693-705. PMID: 32402749
- Serum Depletion of Complement Component 5a Is Associated With Increased Inflammation and Poor Clinical Outcomes in Patients With Perianal Fistulas. | Principe, DR., et al. 2023. Dis Colon Rectum. 66: 288-298. PMID: 35724247
- Inhibiting C5a/C5aR to treat ANCA-associated vasculitides. | Terrier, B. and Karras, A. 2023. Joint Bone Spine. 90: 105472. PMID: 36273796
- The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics. | Ghosh, M. and Rana, S. 2023. Int Immunopharmacol. 118: 110081. PMID: 36989901
- Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. | Li, XX., et al. 2024. Proc Natl Acad Sci U S A. 121: e2314627121. PMID: 38252818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C5a Antibody (2952) | sc-52634 | 100 µg/ml | $322.00 |