C5 Antibody (6A532): sc-70476
- C5 Antibody (6A532) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 100 µg/ml
- raised against the N-terminus of C5 of human origin
- recommended for detection of the N-terminus of C5, intact C5 and C5a of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for C5 Antibody (6A532). This work is in progress.
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C5 Antibody (6A532) is a mouse monoclonal IgG2a antibody that detects C5 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). C5 is a crucial component of the complement system, playing a pivotal role in immune responses by serving as a precursor to the anaphylatoxin C5α, which is released during complement activation. This process is vital for the elimination of pathogens and the modulation of inflammatory responses. C5 protein is primarily located in the plasma and is synthesized by the liver, where C5 undergoes proteolytic cleavage to generate C5α and C5β. The release of C5α is particularly important as C5α binds to specific G protein-coupled receptors on myeloid leukocytes, triggering a cascade of proinflammatory events, including cellular degranulation and cytokine release. The interaction of C5α with C5αR activates signaling pathways that are essential for orchestrating the immune response, highlighting C5′s importance in both innate and adaptive immunity. Anti-C5 antibody (6A532) is an invaluable tool for researchers studying the complement system and its implications in various pathophysiological conditions, including asthma and bacterial meningitis.
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C5 Antibody (6A532) References:
- Single nucleotide polymorphisms of complement component 5 and periodontitis. | Chai, L., et al. 2010. J Periodontal Res. 45: 301-8. PMID: 19909405
- A novel role for the fifth component of complement (C5) in cardiac physiology. | Mullick, A., et al. 2011. PLoS One. 6: e22919. PMID: 21829669
- Structure, function and control of complement C5 and its proteolytic fragments. | Laursen, NS., et al. 2012. Curr Mol Med. 12: 1083-97. PMID: 22812419
- Purification of human complement protein C5. | Sottrup-Jensen, L. and Andersen, GR. 2014. Methods Mol Biol. 1100: 93-102. PMID: 24218252
- Structural basis for therapeutic inhibition of complement C5. | Jore, MM., et al. 2016. Nat Struct Mol Biol. 23: 378-86. PMID: 27018802
- Plasmin as a complement C5 convertase. | Leung, LL. and Morser, J. 2016. EBioMedicine. 5: 20-1. PMID: 27077104
- An inhibitor of complement C5 provides structural insights into activation. | Reichhardt, MP., et al. 2020. Proc Natl Acad Sci U S A. 117: 362-370. PMID: 31871188
- The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. | Wheat, WH., et al. 1987. J Exp Med. 165: 1442-7. PMID: 3572304
- Using genetics to explore complement C5 as a druggable protein in periodontitis. | Alayash, Z., et al. 2024. Front Immunol. 15: 1407431. PMID: 39439802
- Crystallization of human complement component C5. | Discipio, RG., et al. 1998. Acta Crystallogr D Biol Crystallogr. 54: 643-6. PMID: 9761862
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C5 Antibody (6A532) | sc-70476 | 100 µg/ml | $322.00 |