C1QBP Antibody (74.5.2): sc-23885
- C1QBP Antibody (74.5.2) is a mouse monoclonal IgG1 κ C1QBP antibody, cited in 9 publications, provided at 200 µg/ml
- raised against recombinant C1QBP corresponding to mature C1QBP (aa 74-282)
- C1QBP Antibody (74.5.2) is recommended for detection of mature and truncated form of C1QBP of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- Anti-C1QBP Antibody (74.5.2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for C1QBP Antibody (74.5.2) for WB and IHC(P) applications. These reagents are now offered in bundles with C1QBP Antibody (74.5.2) (see ordering information below).
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C1QBP Antibody (74.5.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects C1QBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). C1QBP Antibody (74.5.2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C1QBP, also known as gC1q-R, p32, or hyaluronan-binding protein 1, plays a crucial role in the immune response by binding to the globular heads of C1q molecules, thereby inhibiting C1 activation and modulating the complement system. C1QBP is primarily located in the cytoplasm and mitochondria of cells, where C1QBP is involved in various cellular processes, including apoptosis and cell signaling. C1QBP presence in vascular endothelial cells highlights C1QBP importance in maintaining vascular integrity and regulating inflammatory responses. Additionally, C1QBP is a subunit of the pre-mRNA splicing factor SF2/ASF, linking C1QBP to the regulation of gene expression. The multifunctional nature of C1QBP, with interactions across complement, coagulation, and kinin systems, underscores C1QBP significance in both innate and adaptive immunity, making anti-C1QBP antibody (74.5.2) an essential tool for researchers studying immune mechanisms and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
C1QBP Antibody (74.5.2) References:
- Subcellular targeting of multiligand-binding protein gC1qR. | Dedio, J., et al. 1999. Immunopharmacology. 45: 1-5. PMID: 10614982
- The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis. | Tye, AJ., et al. 2001. J Biol Chem. 276: 17069-75. PMID: 11278463
- C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. | Danet, GH., et al. 2002. Proc Natl Acad Sci U S A. 99: 10441-5. PMID: 12140365
- Classical pathway complement activation on human endothelial cells. | Yin, W., et al. 2007. Mol Immunol. 44: 2228-34. PMID: 17173972
- Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. | Krainer, AR., et al. 1991. Cell. 66: 383-94. PMID: 1830244
- Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2. | Deb, TB. and Datta, K. 1996. J Biol Chem. 271: 2206-12. PMID: 8567680
- Assignment of C1QBP encoding the C1q globular domain binding protein (gC1q-R) to human chromosome 17 band p13.3 by in situ hybridization. | Guo, N., et al. 1997. Cytogenet Cell Genet. 77: 283-4. PMID: 9284938
- The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein. | Dedio, J., et al. 1998. J Immunol. 160: 3534-42. PMID: 9531316
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C1QBP Antibody (74.5.2) | sc-23885 | 200 µg/ml | $322.00 | |||
C1QBP Antibody (74.5.2): m-IgG Fc BP-HRP Bundle | sc-528378 | 200 µg Ab; 10 µg BP | $361.00 | |||
C1QBP Antibody (74.5.2): m-IgGκ BP-HRP Bundle | sc-520741 | 200 µg Ab, 40 µg BP | $361.00 | |||
C1QBP Antibody (74.5.2): m-IgG1 BP-HRP Bundle | sc-542905 | 200 µg Ab; 20 µg BP | $361.00 | |||
C1QBP Antibody (74.5.2) AC | sc-23885 AC | 500 µg/ml, 25% agarose | $424.00 | |||
C1QBP Antibody (74.5.2) HRP | sc-23885 HRP | 200 µg/ml | $322.00 | |||
C1QBP Antibody (74.5.2) FITC | sc-23885 FITC | 200 µg/ml | $336.00 | |||
C1QBP Antibody (74.5.2) PE | sc-23885 PE | 200 µg/ml | $349.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 488 | sc-23885 AF488 | 200 µg/ml | $364.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 546 | sc-23885 AF546 | 200 µg/ml | $364.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 594 | sc-23885 AF594 | 200 µg/ml | $364.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 647 | sc-23885 AF647 | 200 µg/ml | $364.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 680 | sc-23885 AF680 | 200 µg/ml | $364.00 | |||
C1QBP Antibody (74.5.2) Alexa Fluor® 790 | sc-23885 AF790 | 200 µg/ml | $364.00 |