C1QBP Antibody (74.5.2): sc-23885

C1QBP Antibody (74.5.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects C1QBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). C1QBP Antibody (74.5.2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C1QBP, also known as gC1q-R, p32, or hyaluronan-binding protein 1, plays a crucial role in the immune response by binding to the globular heads of C1q molecules, thereby inhibiting C1 activation and modulating the complement system. C1QBP is primarily located in the cytoplasm and mitochondria of cells, where C1QBP is involved in various cellular processes, including apoptosis and cell signaling. C1QBP presence in vascular endothelial cells highlights C1QBP importance in maintaining vascular integrity and regulating inflammatory responses. Additionally, C1QBP is a subunit of the pre-mRNA splicing factor SF2/ASF, linking C1QBP to the regulation of gene expression. The multifunctional nature of C1QBP, with interactions across complement, coagulation, and kinin systems, underscores C1QBP significance in both innate and adaptive immunity, making anti-C1QBP antibody (74.5.2) an essential tool for researchers studying immune mechanisms and related pathologies.

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C1QBP Antibody (74.5.2) References:

1. Subcellular targeting of multiligand-binding protein gC1qR.  |  Dedio, J., et al. 1999. Immunopharmacology. 45: 1-5. PMID: 10614982
2. The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis.  |  Tye, AJ., et al. 2001. J Biol Chem. 276: 17069-75. PMID: 11278463
3. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential.  |  Danet, GH., et al. 2002. Proc Natl Acad Sci U S A. 99: 10441-5. PMID: 12140365
4. Classical pathway complement activation on human endothelial cells.  |  Yin, W., et al. 2007. Mol Immunol. 44: 2228-34. PMID: 17173972
5. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.  |  Krainer, AR., et al. 1991. Cell. 66: 383-94. PMID: 1830244
6. Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2.  |  Deb, TB. and Datta, K. 1996. J Biol Chem. 271: 2206-12. PMID: 8567680
7. Assignment of C1QBP encoding the C1q globular domain binding protein (gC1q-R) to human chromosome 17 band p13.3 by in situ hybridization.  |  Guo, N., et al. 1997. Cytogenet Cell Genet. 77: 283-4. PMID: 9284938
8. The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein.  |  Dedio, J., et al. 1998. J Immunol. 160: 3534-42. PMID: 9531316

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C1QBP Antibody (74.5.2) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-C1QBP Antibody (74.5.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C1QBP Antibody (74.5.2) Specifications

Alternate Product Name: Glycoprotein GC1qBP

Product Clone Name: 74.5.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 74-282

Epitope Target: C1QBP

Epitope Species: human

Product Reactivity/Detection: mature and truncated form of C1QBP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for C1QBP Antibody (74.5.2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin