Yes Antibody (G-6): sc-515247
- Yes Antibody (G-6) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 19-43 near the N-terminus of c-Yes of human origin
- recommended for detection of c-Yes of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Yes Antibody (G-6) for WB applications. This reagent is now offered in a bundle with Yes Antibody (G-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
c-Yes Antibody (G-6) is a mouse monoclonal IgM antibody that detects c-Yes in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-Yes is a crucial member of the Src family of non-receptor tyrosine kinases, which play a significant role in various cellular processes, including proliferation, differentiation, motility, and adhesion. c-Yes is primarily located in the cytoplasm and translocates to the plasma membrane upon activation, which is essential for signal transduction pathways. This localization allows c-Yes to interact with various membrane-associated proteins, thereby influencing cellular responses to external stimuli. The c-Yes gene, mapping to chromosome 18p11.31-p11.21, encodes a 543 amino acid protein that shares over 80% homology with c-Src outside of their unique amino-termini, highlighting the evolutionary conservation and functional importance of these kinases. Anti-c-Yes antibody (G-6) is an invaluable tool for researchers studying the intricate signaling networks mediated by Src family kinases and their implications in cellular behavior and disease states.
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Yes Antibody (G-6) References:
- Immunohistochemical analysis of c-yes and c-erbB-2 oncogene products and p53 tumor suppressor protein in canine mammary tumors. | Rungsipipat, A., et al. 1999. J Vet Med Sci. 61: 27-32. PMID: 10027159
- Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes. | Hansen, RK., et al. 2001. Biochem Biophys Res Commun. 282: 186-93. PMID: 11263990
- The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. | Sommer, S., et al. 2005. J Steroid Biochem Mol Biol. 97: 219-29. PMID: 16289864
- Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis. | Nonomura, T., et al. 2007. Int J Oncol. 30: 105-11. PMID: 17143518
- Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. | Barraclough, J., et al. 2007. Neoplasia. 9: 745-54. PMID: 17898870
- The cysteine-cluster motif of c-Yes, Lyn and FAK as a suppressive module for the kinases. | Rahman, MA., et al. 2008. Oncol Rep. 19: 975-80. PMID: 18357384
- Distribution of c-yes-1 gene product in various cells and tissues. | Sugawara, K., et al. 1991. Br J Cancer. 63: 508-13. PMID: 2021534
- Location of the c-yes gene on the human chromosome and its expression in various tissues. | Semba, K., et al. 1985. Science. 227: 1038-40. PMID: 2983418
- Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. | Ariki, M., et al. 1997. J Biochem. 121: 104-11. PMID: 9058199
- Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. | Han, NM., et al. 1996. Clin Cancer Res. 2: 1397-404. PMID: 9816313
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Yes Antibody (G-6) | sc-515247 | 200 µg/ml | $316.00 | |||
Yes Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-550761 | 200 µg Ab; 40 µg BP | $354.00 | |||
Yes (G-6) Neutralizing Peptide | sc-515247 P | 100 µg/0.5 ml | $68.00 |