c-Rel Antibody (B-6): sc-6955

c-Rel Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-Rel of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC). c-Rel Antibody (B-6) is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. c-Rel is a vital component of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling pathway, which is essential for regulating immune responses, cell proliferation, and survival. Through binding to specific κB sites in promoter regions of target genes, c-Rel plays a crucial role in transcriptional activation of immunoglobulin kappa light chain genes, thereby influencing B cell development and function. Proper regulation of c-Rel is important because dysregulation can lead to various immune disorders and contribute to cancer development. In contrast to v-Rel, which lacks a functional C-terminal transactivation domain and disrupts normal NFκB signaling, c-Rel maintains a role as a transcriptional activator, highlighting significance in maintaining cellular homeostasis and immune function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

c-Rel Antibody (B-6) References:

1. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.  |  Chen, Y., et al. 2004. Mol Cell Biol. 24: 3048-56. PMID: 15024091
2. c-rel activates but v-rel suppresses transcription from kappa B sites.  |  Inoue, J., et al. 1991. Proc Natl Acad Sci U S A. 88: 3715-9. PMID: 2023921
3. Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.  |  Ghosh, S., et al. 1990. Cell. 62: 1019-29. PMID: 2203532
4. The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.  |  Bull, P., et al. 1990. Mol Cell Biol. 10: 5473-85. PMID: 2204816
5. Transactivation of gene expression by nuclear and cytoplasmic rel proteins.  |  Hannink, M. and Temin, HM. 1989. Mol Cell Biol. 9: 4323-36. PMID: 2555689
6. c-Rel and its many roles in cancer: an old story with new twists.  |  Hunter, JE., et al. 2016. Br J Cancer. 114: 1-6. PMID: 26757421
7. Transcriptional autoregulation of the proto-oncogene fos.  |  Sassone-Corsi, P., et al. 1988. Nature. 334: 314-9. PMID: 2839774
8. Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T.  |  Gilmore, TD. and Temin, HM. 1986. Cell. 44: 791-800. PMID: 3004745
9. c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.  |  Leslie, J., et al. 2020. Nat Metab. 2: 1350-1367. PMID: 33168981
10. c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.  |  Leslie, J., et al. 2023. Hepatology. 78: 1050-1063. PMID: 36089330
11. Isolation and characterization of reticuloendotheliosis virus transformed bone marrow cells.  |  Franklin, RB., et al. 1974. Intervirology. 3: 342-52. PMID: 4443191

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Rel Antibody (B-6) has 132 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Rel Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Rel Antibody (B-6) Specifications

Alternate Product Name: c-Rel

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 1-300

Epitope Target: c-Rel

Epitope Species: human

Product Reactivity/Detection: c-Rel p75

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 132 citations in various scientific publications

Available Conjugates/Forms for c-Rel Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent