c-IAP1 Antibody (F-4): sc-271419

c-IAP1 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-IAP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-IAP1 Antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. c-IAP1, also known as BIRC2, plays a crucial role in regulating apoptosis, which is the process of programmed cell death essential for maintaining cellular homeostasis and immune responses. By inhibiting apoptosis, c-IAP1 helps prevent premature cell death, particularly during inflammation and infection, allowing survival of immune cells necessary for an effective immune response. This function is particularly important in cancer, where apoptosis evasion can contribute to tumor growth and therapy resistance. c-IAP1 achieves anti-apoptotic effects through interactions with key signaling molecules, including TRAF1 and TRAF2, involved in the tumor necrosis factor (TNF) signaling pathway. c-IAP1′s ability to modulate these interactions highlights significance in both normal physiological processes and pathological conditions, making c-IAP1 a valuable target for therapeutic interventions.

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c-IAP1 Antibody (F-4) References:

1. Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.  |  Zhao, Y., et al. 2007. J Biol Chem. 282: 7777-82. PMID: 17220297
2. c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.  |  Xu, W., et al. 2012. Molecules. 17: 12086-101. PMID: 23085658
3. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.  |  Tencer, AH., et al. 2023. Nat Struct Mol Biol. 30: 1265-1274. PMID: 37524969
4. NAP1L1 regulates BIRC2 ubiquitination modification via E3 ubiquitin ligase UBR4 and hence determines hepatocellular carcinoma progression.  |  Zhang, SL., et al. 2024. Cell Death Discov. 10: 154. PMID: 38538582
5. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis.  |  Beidler, DR., et al. 1995. J Biol Chem. 270: 16526-8. PMID: 7542648
6. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.  |  Bump, NJ., et al. 1995. Science. 269: 1885-8. PMID: 7569933
7. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein.  |  Xue, D. and Horvitz, HR. 1995. Nature. 377: 248-51. PMID: 7675111
8. Expression of baculovirus P35 prevents cell death in Drosophila.  |  Hay, BA., et al. 1994. Development. 120: 2121-9. PMID: 7925015
9. Control of programmed cell death by the baculovirus genes p35 and iap.  |  Clem, RJ. and Miller, LK. 1994. Mol Cell Biol. 14: 5212-22. PMID: 8035800
10. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.  |  Rothe, M., et al. 1995. Cell. 83: 1243-52. PMID: 8548810
11. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.  |  Uren, AG., et al. 1996. Proc Natl Acad Sci U S A. 93: 4974-8. PMID: 8643514
12. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.  |  Duckett, CS., et al. 1996. EMBO J. 15: 2685-94. PMID: 8654366

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-IAP1 Antibody (F-4) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-c-IAP1 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-IAP1 Antibody (F-4) Specifications

Alternate Product Name: c-IAP1

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 111-193

Epitope Target: c-IAP1 (inhibitor of apoptosis protein 1)

Epitope Species: human

Product Reactivity/Detection: c-IAP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for c-IAP1 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin