c-Fos Antibody (C-10): sc-271243
- c-Fos Antibody (C-10) is a mouse monoclonal IgG2a κ, cited in 71 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 120-155 within an internal region of c-Fos of human origin
- c-Fos Antibody (C-10) is recommended for detection of c-Fos, Fos B, Fra-1 and Fra-2 of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- TransCruz reagent for ChIP application (sc-271243 X, 200 µg/0.1 ml)
- Anti-c-Fos Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for c-Fos Antibody (C-10) for WB and IHC(P) applications. These reagents are now offered in bundles with c-Fos Antibody (C-10) (see ordering information below).
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c-Fos Antibody (C-10) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 120-155 of human c-Fos, a rapidly induced nuclear phosphoprotein crucial for transcriptional regulation. Anti-c-Fos antibody (C-10) recognizes an epitope within this internal region and demonstrates remarkably broad species cross-reactivity, detecting c-Fos, FosB, Fra-1, and Fra-2 in mouse, rat, human, equine, canine, bovine, porcine, and avian samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. c-Fos monoclonal antibody (C-10) is available in non-conjugated form and multiple conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, offering versatility for diverse experimental needs. The sophistication of c-Fos regulation emerges through critical post-translational modifications: phosphorylation enhances c-Fos′s DNA binding capacity and protein interactions, while ubiquitination targets c-Fos for proteasomal degradation, creating a dynamic system for modulating gene expression. Through heterodimerization with Jun family proteins, c-Fos forms the AP-1 transcription factor complex, orchestrating the expression of genes controlling cell proliferation, differentiation, and survival. This complex regulatory network makes c-Fos an important marker for studying signal transduction pathways, particularly in contexts of oncogenesis, neurobiology, and stress responses. Through these diverse cellular functions, c-Fos (C-10) antibody serves as a valuable tool for investigating transcriptional regulation and cellular signaling mechanisms across multiple species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
c-Fos Antibody (C-10) | sc-271243 | 200 µg/ml | $316.00 | |||
c-Fos Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-525793 | 200 µg Ab; 10 µg BP | $354.00 | |||
c-Fos Antibody (C-10): m-IgG2a BP-HRP Bundle | sc-546417 | 200 µg Ab; 10 µg BP | $354.00 | |||
c-Fos Antibody (C-10) X | sc-271243 X | 200 µg/0.1 ml | $316.00 | |||
c-Fos Antibody (C-10) AC | sc-271243 AC | 500 µg/ml, 25% agarose | $416.00 | |||
c-Fos Antibody (C-10) HRP | sc-271243 HRP | 200 µg/ml | $316.00 | |||
c-Fos Antibody (C-10) FITC | sc-271243 FITC | 200 µg/ml | $330.00 | |||
c-Fos Antibody (C-10) PE | sc-271243 PE | 200 µg/ml | $343.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 488 | sc-271243 AF488 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 546 | sc-271243 AF546 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 594 | sc-271243 AF594 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 647 | sc-271243 AF647 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 680 | sc-271243 AF680 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (C-10) Alexa Fluor® 790 | sc-271243 AF790 | 200 µg/ml | $357.00 | |||
c-Fos (C-10) Neutralizing Peptide | sc-271243 P | 100 µg/0.5 ml | $68.00 |