BXDC2 Antibody (C-1): sc-373680
- BXDC2 Antibody (C-1) is a mouse monoclonal IgG1 κ BXDC2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 299-332 near the C-terminus of BXDC2 of human origin
- BXDC2 Antibody (C-1) is recommended for detection of BXDC2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BXDC2 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BXDC2 Antibody (C-1) for WB and IHC(P) applications. These reagents are now offered in bundles with BXDC2 Antibody (C-1) (see ordering information below).
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BXDC2 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BXDC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BXDC2 (C-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BXDC2, or Brix domain-containing protein 2, is a crucial 306 amino acid nuclear protein encoded by the human gene BXDC2, which plays a significant role in ribosome biogenesis. Specifically, BXDC2 contains a Brix domain, a structural motif that is homologous to the yeast protein Pitx1, which is part of a complex essential for the formation of the 60S ribosomal subunit. This complex also includes BXDC5, BXDC1, and PPAN, highlighting the collaborative nature of ribosomal assembly. Proper functioning of BXDC2 is vital for maintaining cellular protein synthesis, as disruptions in ribosome biogenesis can lead to various diseases, including cancer and genetic disorders. Using anti-BXDC2 antibody (C-1) in research can provide insights into the mechanisms of ribosome assembly and the potential implications of BXDC2 in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BXDC2 Antibody (C-1) References:
- Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. | Strezoska, Z., et al. 2000. Mol Cell Biol. 20: 5516-28. PMID: 10891491
- Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. | Sasaki, T., et al. 2000. Mol Cell Biol. 20: 7971-9. PMID: 11027267
- Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. | Kaser, A., et al. 2001. Biol Chem. 382: 1637-47. PMID: 11843177
- Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. | Morita, D., et al. 2002. J Biol Chem. 277: 28780-6. PMID: 12048200
- The DNA sequence and analysis of human chromosome 6. | Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. | McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
- The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype? | Olsson, KS., et al. 2007. Eur J Haematol. 79: 429-34. PMID: 17924859
- A disease state mutation unfolds the parkin ubiquitin-like domain. | Safadi, SS. and Shaw, GS. 2007. Biochemistry. 46: 14162-9. PMID: 18004887
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BXDC2 Antibody (C-1) | sc-373680 | 200 µg/ml | $316.00 | |||
BXDC2 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-529537 | 200 µg Ab; 10 µg BP | $354.00 | |||
BXDC2 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-522457 | 200 µg Ab, 40 µg BP | $354.00 | |||
BXDC2 Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-543565 | 200 µg Ab; 20 µg BP | $354.00 | |||
BXDC2 Antibody (C-1) AC | sc-373680 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BXDC2 Antibody (C-1) HRP | sc-373680 HRP | 200 µg/ml | $316.00 | |||
BXDC2 Antibody (C-1) FITC | sc-373680 FITC | 200 µg/ml | $330.00 | |||
BXDC2 Antibody (C-1) PE | sc-373680 PE | 200 µg/ml | $343.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 488 | sc-373680 AF488 | 200 µg/ml | $357.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 546 | sc-373680 AF546 | 200 µg/ml | $357.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 594 | sc-373680 AF594 | 200 µg/ml | $357.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 647 | sc-373680 AF647 | 200 µg/ml | $357.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 680 | sc-373680 AF680 | 200 µg/ml | $357.00 | |||
BXDC2 Antibody (C-1) Alexa Fluor® 790 | sc-373680 AF790 | 200 µg/ml | $357.00 | |||
BXDC2 (C-1) Neutralizing Peptide | sc-373680 P | 100 µg/0.5 ml | $68.00 |