BSPII Antibody (LFMb-25): sc-73630
- BSPII Antibody (LFMb-25) is a mouse monoclonal IgG1 κ, cited in 22 publications, provided at 200 µg/ml
- raised against amino acids 257-276 of BSPII of human origin
- Anti-BSPII Antibody (LFMb-25) is recommended for detection of BSPII of mouse, rat, human, monkey and bovine origin by WB, IP, IF and IHC(P)
- Anti-BSPII Antibody (LFMb-25) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BSPII Antibody (LFMb-25) for WB and IHC(P) applications. These reagents are now offered in bundles with BSPII Antibody (LFMb-25) (see ordering information below).
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BSPII Antibody (LFMb-25) is a mouse monoclonal IgG1 kappa light chain antibody that detects BSPII in mouse, rat, human, monkey, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. anti-BSPII antibody (LFMb-25) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BSPII, also known as bone sialoprotein II, integrin-binding sialoprotein, or BSP, is a secreted acidic glycoprotein synthesized by osteoblasts, osteocytes, osteoclasts, and hypertrophic chondrocytes, playing a crucial role in bone matrix structure. BSPII (LFMb-25) monoclonal antibody recognizes a protein essential for nucleating hydroxyapatite crystal formation, which drives initial mineralization of bone, cementum, and dentin. BSPII belongs to the SIBLING family of proteins and contains an RGD sequence that interacts with the vitronectin receptor Integrin αV, facilitating cell attachment and influencing bone remodeling processes. BSPII expression appears in various cancers, including lung, thyroid, breast, and prostate cancers, highlighting its potential as a biomarker for tumor progression and a target for therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BSPII Antibody (LFMb-25) References:
- Mutual induction of noncollagenous bone proteins at the interface between epithelial cells and fibroblasts from human periodontal ligament. | Shimonishi, M., et al. 2008. J Periodontal Res. 43: 64-75. PMID: 18230108
- Effect of osteogenic induction on the in vitro differentiation of human embryonic stem cells cocultured with periodontal ligament fibroblasts. | Inanç, B., et al. 2007. Artif Organs. 31: 792-800. PMID: 18273446
- Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans. | Knabe, C., et al. 2008. Biomaterials. 29: 2249-58. PMID: 18289665
- Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. | Bellahcène, A., et al. 2008. Nat Rev Cancer. 8: 212-26. PMID: 18292776
- Bone sialoprotein and its transcriptional regulatory mechanism. | Ogata, Y. 2008. J Periodontal Res. 43: 127-35. PMID: 18302613
- Effects of medullary reaming on fracture healing. Tibial osteotomies in rabbits. | Bråten, M., et al. 1990. Acta Orthop Scand. 61: 327-9. PMID: 2402984
- Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. | Kim, RH., et al. 1994. Matrix Biol. 14: 31-40. PMID: 8061918
- The development of sequence-tagged sites for human chromosome 4. | Goold, RD., et al. 1993. Hum Mol Genet. 2: 1271-88. PMID: 8401509
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BSPII Antibody (LFMb-25) | sc-73630 | 200 µg/ml | $316.00 | |||
BSPII Antibody (LFMb-25): m-IgG Fc BP-HRP Bundle | sc-527010 | 200 µg Ab; 10 µg BP | $354.00 | |||
BSPII Antibody (LFMb-25): m-IgG1 BP-HRP Bundle | sc-532383 | 200 µg Ab; 20 µg BP | $354.00 | |||
BSPII Antibody (LFMb-25) AC | sc-73630 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BSPII Antibody (LFMb-25) HRP | sc-73630 HRP | 200 µg/ml | $316.00 | |||
BSPII Antibody (LFMb-25) FITC | sc-73630 FITC | 200 µg/ml | $330.00 | |||
BSPII Antibody (LFMb-25) PE | sc-73630 PE | 200 µg/ml | $343.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 488 | sc-73630 AF488 | 200 µg/ml | $357.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 546 | sc-73630 AF546 | 200 µg/ml | $357.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 594 | sc-73630 AF594 | 200 µg/ml | $357.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 647 | sc-73630 AF647 | 200 µg/ml | $357.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 680 | sc-73630 AF680 | 200 µg/ml | $357.00 | |||
BSPII Antibody (LFMb-25) Alexa Fluor® 790 | sc-73630 AF790 | 200 µg/ml | $357.00 |