BSPII Inhibitors
The class of BSPII inhibitors encompasses a diverse range of chemicals that hold promise for modulating the activity of BSPII. These compounds target various cellular pathways and processes, influencing calcium signaling, mitochondrial function, and calcium homeostasis. 2-Aminoethoxydiphenyl Borate (2-APB) indirectly targets BSPII by inhibiting inositol trisphosphate receptors (IP3R), affecting calcium release. Nifedipine, a calcium channel blocker, modulates cellular calcium levels, providing an avenue for indirect BSPII inhibition. U73122, a phospholipase C (PLC) inhibitor, could impact BSPII activity by influencing IP3-mediated signaling pathways.
Dantrolene, a ryanodine receptor antagonist, and SKF-96365, a broad-spectrum calcium channel blocker, both target cellular calcium levels, offering routes for indirect BSPII inhibition. Ruthenium Red, known for inhibiting various calcium channels, may impact BSPII by altering calcium homeostasis. TMB-8, an inhibitor of store-operated calcium channels (SOCCs), presents another avenue for exploring indirect BSPII inhibition. CGP-37157, a mitochondrial Na+/Ca2+ exchange inhibitor, targets mitochondrial calcium exchange, influencing BSPII activity. Thapsigargin, a sarco/endoplasmic reticulum calcium ATPase (SERCA) inhibitor, and Gadolinium(III) chloride, a broad-spectrum calcium channel blocker, both impact cellular calcium homeostasis, offering avenues for indirect BSPII inhibition. Capsazepine, a TRPV1 antagonist, and YM-58483, a store-operated calcium entry (SOCE) inhibitor, modulate calcium influx, providing additional routes for exploring indirect BSPII inhibition. The class of BSPII inhibitors provides a diverse toolkit for investigating the dynamic interplay between cellular processes and BSPII activity, contributing to a deeper understanding of this protein's role in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a chemical that inhibits inositol trisphosphate receptors (IP3R), which may indirectly modulate BSPII activity. IP3R is involved in calcium signaling, and alterations in calcium levels can impact various cellular processes, potentially influencing BSPII function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that may indirectly influence BSPII by modulating calcium levels. Calcium channels play a crucial role in cellular calcium homeostasis, and changes in calcium concentrations can affect various cellular processes. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a ryanodine receptor antagonist that may indirectly modulate BSPII activity. Ryanodine receptors are calcium release channels located on the endoplasmic reticulum, and their inhibition can impact cellular calcium levels. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is a broad-spectrum calcium channel blocker that may indirectly influence BSPII by modulating cellular calcium levels. Calcium channels play a crucial role in cellular calcium homeostasis, and changes in calcium concentrations can affect various cellular processes. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium red is a compound known to inhibit various calcium channels, including ryanodine receptors. Its potential to indirectly modulate BSPII arises from its ability to impact cellular calcium levels. Changes in calcium concentrations can influence various cellular processes, potentially including those related to BSPII function. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8 is an inhibitor of calcium influx through store-operated calcium channels (SOCCs). By modulating SOCC activity, TMB-8 may indirectly influence BSPII by altering cellular calcium levels. Changes in calcium concentrations can impact various cellular processes, potentially including those related to BSPII function. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP-37157 is a mitochondrial Na+/Ca2+ exchange inhibitor that may indirectly modulate BSPII by impacting cellular calcium homeostasis. Mitochondria play a role in regulating cellular calcium levels, and alterations in mitochondrial calcium handling can influence various cellular processes, potentially including those related to BSPII function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum calcium ATPase (SERCA) inhibitor that could potentially impact BSPII activity. SERCA is responsible for pumping calcium into the endoplasmic reticulum, and its inhibition can lead to alterations in cellular calcium levels. Changes in calcium concentrations can influence various cellular processes, potentially including those related to BSPII function. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium(III) chloride is a broad-spectrum calcium channel blocker that may indirectly influence BSPII by modulating cellular calcium levels. Calcium channels play a crucial role in cellular calcium homeostasis, and changes in calcium concentrations can affect various cellular processes. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capsazepine is a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist that may indirectly modulate BSPII activity. TRPV1 channels are involved in calcium influx, and their inhibition can lead to alterations in cellular calcium levels. Changes in calcium concentrations can influence various cellular processes, potentially including those related to BSPII function. | ||||||