BRMS1L Antibody (E-2): sc-518200
- BRMS1L Antibody (E-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 183-206 of BRMS1L of human origin
- recommended for detection of BRMS1L of human origin by WB, IP, IF and ELISA
- Anti-BRMS1L Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for BRMS1L Antibody (E-2) for WB applications. These reagents are now offered in bundles with BRMS1L Antibody (E-2) (see ordering information below).
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BRMS1L Antibody (E-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects BRMS1L of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BRMS1L antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BRMS1L, or breast cancer metastasis-suppressor 1-like, is a 323 amino acid protein that plays a crucial role in cellular processes by localizing to the nucleus and functioning as a component of the mSin3A/HDAC1 (histone deacetylase) complex. This localization enables BRMS1L to participate in the regulation of gene expression through HDAC1-dependent transcriptional repression, which is vital for maintaining normal cellular functions and preventing uncontrolled cell growth. BRMS1L has been shown to inhibit cell proliferation in lung cancer tissues, highlighting a potential role in tumor suppression. The gene encoding BRMS1L is located on human chromosome 14, a region that contains over 700 genes and is implicated in various genetic disorders, including those related to Alzheimer′s disease and α1-antitrypsin deficiency.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BRMS1L Antibody (E-2) References:
- Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). | Kuzmichev, A., et al. 2002. Mol Cell Biol. 22: 835-48. PMID: 11784859
- Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. | Meehan, WJ., et al. 2004. J Biol Chem. 279: 1562-9. PMID: 14581478
- Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. | Nikolaev, AY., et al. 2004. Biochem Biophys Res Commun. 323: 1216-22. PMID: 15451426
- Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population. | Albani, D., et al. 2007. Neurobiol Aging. 28: 1682-8. PMID: 16952411
- Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies. | Micci, F., et al. 2007. Virchows Arch. 450: 559-65. PMID: 17406891
- A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. | Martín-Subero, JI., et al. 2007. Leukemia. 21: 1532-44. PMID: 17495977
- The genetics of very early onset Alzheimer disease. | Filley, CM., et al. 2007. Cogn Behav Neurol. 20: 149-56. PMID: 17846513
- The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency. | Cruz, PE., et al. 2007. Pharmacogenomics. 8: 1191-8. PMID: 17924834
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRMS1L Antibody (E-2) | sc-518200 | 200 µg/ml | $322.00 | |||
BRMS1L Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-551040 | 200 µg Ab; 10 µg BP | $361.00 | |||
BRMS1L Antibody (E-2): m-IgG2a BP-HRP Bundle | sc-551041 | 200 µg Ab; 10 µg BP | $361.00 | |||
BRMS1L Antibody (E-2) AC | sc-518200 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BRMS1L Antibody (E-2) HRP | sc-518200 HRP | 200 µg/ml | $322.00 | |||
BRMS1L Antibody (E-2) FITC | sc-518200 FITC | 200 µg/ml | $336.00 | |||
BRMS1L Antibody (E-2) PE | sc-518200 PE | 200 µg/ml | $349.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 488 | sc-518200 AF488 | 200 µg/ml | $364.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 546 | sc-518200 AF546 | 200 µg/ml | $364.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 594 | sc-518200 AF594 | 200 µg/ml | $364.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 647 | sc-518200 AF647 | 200 µg/ml | $364.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 680 | sc-518200 AF680 | 200 µg/ml | $364.00 | |||
BRMS1L Antibody (E-2) Alexa Fluor® 790 | sc-518200 AF790 | 200 µg/ml | $364.00 |