BRIDGE-1 Antibody (ZZ07): sc-100996
- BRIDGE-1 Antibody (ZZ07) is a mouse monoclonal IgG1 κ BRIDGE-1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant BRIDGE-1 of human origin
- recommended for detection of BRIDGE-1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRIDGE-1 Antibody (ZZ07). This work is in progress.
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BRIDGE-1 Antibody (ZZ07) is a mouse monoclonal IgG1 kappa light chain antibody that detects BRIDGE-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BRIDGE-1 antibody (ZZ07) is available as the non-conjugated format. BRIDGE-1 protein plays a crucial role in regulating insulin and other islet genes within the pancreas, making BRIDGE-1 essential for maintaining glucose homeostasis. BRIDGE-1 protein is predominantly localized in the nucleus of pancreatic beta cells, where BRIDGE-1 is involved in transcriptional regulation of insulin gene expression. BRIDGE-1 in the nucleus interacts with various transcription factors and coactivators, such as E2A, CBP, and p300, facilitating transcriptional activation of insulin and other critical genes. BRIDGE-1 contains a conserved PDZ-like domain that mediates protein-protein interactions, which are vital for intracellular signaling processes. BRIDGE-1′s interaction with members of the E2A family of transcription factors, such as E12 and E47, suggests a novel mechanism for insulin gene expression regulation, highlighting BRIDGE-1′s importance in pancreatic function and metabolic regulation.
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BRIDGE-1 Antibody (ZZ07) References:
- Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. | Thomas, MK., et al. 1999. Mol Cell Biol. 19: 8492-504. PMID: 10567574
- Homologous DNA sequences and cellular factors are implicated in the control of glucagon and insulin gene expression. | Cordier-Bussat, M., et al. 1995. Mol Cell Biol. 15: 3904-16. PMID: 7791796
- The insulin gene contains multiple transcriptional elements that respond to glucose. | German, MS. and Wang, J. 1994. Mol Cell Biol. 14: 4067-75. PMID: 8196645
- Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. | Eckner, R., et al. 1996. Genes Dev. 10: 2478-90. PMID: 8843199
- PDZ domains bind carboxy-terminal sequences of target proteins. | Saras, J. and Heldin, CH. 1996. Trends Biochem Sci. 21: 455-8. PMID: 9009824
- p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. | Qiu, Y., et al. 1998. Mol Cell Biol. 18: 2957-64. PMID: 9566915
- cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). | Watanabe, TK., et al. 1998. Genomics. 50: 241-50. PMID: 9653651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRIDGE-1 Antibody (ZZ07) | sc-100996 | 100 µg/ml | $339.00 |