BRIDGE-1 Antibody (D-4): sc-376363
- BRIDGE-1 Antibody (D-4) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 31-185 mapping within an internal region of BRIDGE-1 of human origin
- Anti-BRIDGE-1 Antibody (D-4) is recommended for detection of BRIDGE-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BRIDGE-1 Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRIDGE-1 Antibody (D-4). This work is in progress.
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SEE ALSO...
BRIDGE-1 Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects BRIDGE-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BRIDGE-1 is a crucial protein that plays a significant role in regulating insulin and other islet genes within the pancreas, making BRIDGE-1 vital for maintaining glucose homeostasis. BRIDGE-1 is predominantly localized in the nucleus of pancreatic β-cells, where BRIDGE-1 is involved in the transcriptional regulation of insulin gene expression. BRIDGE-1′s presence in the nucleus allows interaction with various transcription factors and coactivators, such as CBP and p300, facilitating gene transcription activation. BRIDGE-1 contains a conserved PDZ-like domain essential for mediating protein-protein interactions, which are critical for intracellular signaling processes. BRIDGE-1′s interaction with members of the E2A family of transcription factors, specifically E12 and E47, suggests a novel mechanism for insulin gene expression regulation, highlighting BRIDGE-1′s importance in pancreatic function and metabolic regulation. Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, BRIDGE-1 (D-4) antibody is a versatile tool for researchers studying insulin regulation and pancreatic β-cell biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRIDGE-1 Antibody (D-4) | sc-376363 | 200 µg/ml | $322.00 | |||
BRIDGE-1 Antibody (D-4) AC | sc-376363 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BRIDGE-1 Antibody (D-4) HRP | sc-376363 HRP | 200 µg/ml | $322.00 | |||
BRIDGE-1 Antibody (D-4) FITC | sc-376363 FITC | 200 µg/ml | $336.00 | |||
BRIDGE-1 Antibody (D-4) PE | sc-376363 PE | 200 µg/ml | $349.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 488 | sc-376363 AF488 | 200 µg/ml | $364.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 546 | sc-376363 AF546 | 200 µg/ml | $364.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 594 | sc-376363 AF594 | 200 µg/ml | $364.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 647 | sc-376363 AF647 | 200 µg/ml | $364.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 680 | sc-376363 AF680 | 200 µg/ml | $364.00 | |||
BRIDGE-1 Antibody (D-4) Alexa Fluor® 790 | sc-376363 AF790 | 200 µg/ml | $364.00 |