BPGM Antibody (B-11): sc-393964

BPGM Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects BPGM (2,3-bisphosphoglycerate mutase) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BPGM is a 259 amino acid protein that belongs to the phosphoglycerate mutase family and functions as a homodimer, playing a vital role in the regulation of hemoglobin oxygen affinity. BPGM (B-11) antibody catalyzes the conversion of 3-phospho-D-glyceroyl phosphate to 2,3-bisphospho-D-glycerate (2,3-BPG), a critical reaction for maintaining the appropriate concentration of 2,3-BPG within the cell. This regulation is essential because 2,3-BPG binds to hemoglobin, facilitating the release of oxygen to tissues, which is crucial for cellular respiration and overall metabolic function. The gene encoding BPGM is located on human chromosome 7, a region that contains over 1,000 genes and accounts for nearly 5% of the human genome. Notably, mutations in genes on chromosome 7 have been associated with various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting the importance of BPGM in both normal physiology and disease states. Anti-BPGM antibody (B-11) is an invaluable tool for researchers studying oxygen transport and related metabolic pathways.

The preferred BPGM antibody is BPGM Antibody (C-4): sc-373819.