BMP-9 Antibody (E-2): sc-515249

BMP-9 Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects bone morphogenic protein-9 (BMP-9) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-9 is a crucial member of the transforming growth factor-beta (TGF-beta) superfamily, primarily involved in tissue morphogenesis, particularly in the development of bone and connective tissues. BMP-9 monoclonal antibody (E-2) recognizes specific receptors on liver cells, such as HepG2, where BMP-9 stimulates cell proliferation and plays a vital role in regulating blood glucose levels—an effect distinct from TGF-beta. Anti-BMP-9 antibody (E-2) has helped researchers demonstrate that BMP-9 administration or BMP-9 encoding adenoviral vectors can enhance bone regeneration in ex vivo settings and in immune-deficient animal models. This multifaceted functionality of BMP-9 underscores its potential as a target for therapeutic interventions in bone-related disorders and metabolic diseases, making anti-BMP-9 antibody (E-2) an invaluable tool for researchers exploring these critical biological processes.

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BMP-9 Antibody (E-2) References:

1. Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases.  |  Herrera, B., et al. 2014. Int J Mol Sci. 15: 5199-220. PMID: 24670474
2. BMP-9 dependent pathways required for the chondrogenic differentiation of pluripotent stem cells.  |  Cheng, A., et al. 2016. Differentiation. 92: 298-305. PMID: 27056281
3. BMP-2 and BMP-9 binding specificities with ALK-3 in aqueous solution with dynamics.  |  Coskuner, O. and Uversky, VN. 2017. J Mol Graph Model. 77: 181-188. PMID: 28869862
4. Role of BMP-9 in human liver disease.  |  John, M., et al. 2019. Gut. 68: 2097-2100. PMID: 30343271
5. Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension.  |  Tu, L., et al. 2019. Circ Res. 124: 846-855. PMID: 30636542
6. Effect of BMP-9 on endothelial cells and its role in atherosclerosis.  |  Hassanisaber, H., et al. 2019. Front Biosci (Landmark Ed). 24: 994-1023. PMID: 30844726
7. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells.  |  Tao, B., et al. 2020. J Biol Chem. 295: 18179-18188. PMID: 33097593
8. Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration.  |  Bharadwaz, A. and Jayasuriya, AC. 2021. Mater Sci Eng C Mater Biol Appl. 120: 111748. PMID: 33545890
9. Osteoinductive potential of recombinant BMP-9 in bone defects of mice treated with antiresorptive agents.  |  Fujioka-Kobayashi, M., et al. 2022. Int J Oral Maxillofac Surg. 51: 566-575. PMID: 34454793
10. Intestinal BMP-9 locally upregulates FGF19 and is down-regulated in obese patients with diabetes.  |  Drexler, S., et al. 2023. Mol Cell Endocrinol. 570: 111934. PMID: 37085108

The preferred BMP-9 antibody is BMP-9 Antibody (H-3): sc-514211.