BMP-8 Antibody (H-4): sc-515399
- BMP-8 Antibody (H-4) is a mouse monoclonal IgG2a κ BMP-8 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 265-287 at the N-terminus of BMP-8B of human origin
- BMP-8 Antibody (H-4) is recommended for detection of precursor and mature BMP-8A and BMP-8B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BMP-8 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BMP-8 Antibody (H-4) for WB applications. These reagents are now offered in bundles with BMP-8 Antibody (H-4) (see ordering information below).
BMP-8 Antibody (H-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects BMP-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-8 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Bone morphogenic proteins (BMPs), which are part of the TGFβ superfamily, play a crucial role in cartilage and bone formation, making BMPs essential for skeletal development and repair. BMP-8 is involved in early developmental processes, with expression largely absent in adult tissues, indicating BMP-8′s significance during embryogenesis. BMP-8 exists in two isoforms, BMP-8A and BMP-8B, which are encoded by distinct genes and may have unique functions in development. BMP-8 interacts with other BMPs, such as BMP-2 and BMP-4, which activate the Smad signaling pathway, further underscoring BMP-8′s importance in orchestrating cellular responses during development. BMP-8′s ability to influence these pathways highlights BMP-8′s potential as a target for therapeutic interventions in conditions related to bone and cartilage disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BMP-8 Antibody (H-4) References:
- Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation. | van der Horst, G., et al. 2002. Bone. 31: 661-9. PMID: 12531559
- Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. | Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
- The transforming growth factor-beta family. | Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
- Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. | Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
- Novel regulators of bone formation: molecular clones and activities. | Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
- Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. | Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
- A human Mad protein acting as a BMP-regulated transcriptional activator. | Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
- Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. | Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. | McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMP-8 Antibody (H-4) | sc-515399 | 200 µg/ml | $316.00 | |||
BMP-8 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-531352 | 200 µg Ab; 10 µg BP | $354.00 | |||
BMP-8 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-525022 | 200 µg Ab, 40 µg BP | $354.00 | |||
BMP-8 Antibody (H-4): m-IgG2a BP-HRP Bundle | sc-547769 | 200 µg Ab; 10 µg BP | $354.00 | |||
BMP-8 Antibody (H-4) AC | sc-515399 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BMP-8 Antibody (H-4) HRP | sc-515399 HRP | 200 µg/ml | $316.00 | |||
BMP-8 Antibody (H-4) FITC | sc-515399 FITC | 200 µg/ml | $330.00 | |||
BMP-8 Antibody (H-4) PE | sc-515399 PE | 200 µg/ml | $343.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 488 | sc-515399 AF488 | 200 µg/ml | $357.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 546 | sc-515399 AF546 | 200 µg/ml | $357.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 594 | sc-515399 AF594 | 200 µg/ml | $357.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 647 | sc-515399 AF647 | 200 µg/ml | $357.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 680 | sc-515399 AF680 | 200 µg/ml | $357.00 | |||
BMP-8 Antibody (H-4) Alexa Fluor® 790 | sc-515399 AF790 | 200 µg/ml | $357.00 | |||
BMP-8 (H-4) Neutralizing Peptide | sc-515399 P | 100 µg/0.5 ml | $68.00 |