BMP-7 Antibody (4E7): sc-53917

BMP-7 Antibody (4E7) is a mouse monoclonal IgG1 kappa light chain antibody that detects BMP-7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BMP-7 antibody (4E7) is available as a non-conjugated format. Bone morphogenic proteins (BMPs) are critical members of the transforming growth factor-beta (TGFβ) superfamily, playing essential roles in regulating bone and cartilage formation. BMP-7 promotes osteogenesis and chondrogenesis, making BMP-7 vital for skeletal development and repair. BMP-7 is primarily located in the extracellular matrix and secreted by various cell types, including osteoblasts and chondrocytes, which underscores BMP-7′s importance in signaling pathways that govern bone and cartilage homeostasis. BMP-7 has been shown to interact with specific receptors, such as activin-like kinase (ALK) receptors, which are crucial for initiating downstream signaling cascades that lead to cellular differentiation and tissue regeneration. BMP-7′s ability to modulate these pathways highlights potential therapeutic applications in treating bone-related disorders and injuries.

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BMP-7 Antibody (4E7) References:

1. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.  |  Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
2. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
3. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.  |  Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
4. Novel regulators of bone formation: molecular clones and activities.  |  Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
5. BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy.  |  Elmadbouh, I. and Singla, DK. 2021. Cells. 10: PMID: 34685620
6. BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease.  |  Peng, W., et al. 2022. Cell Death Dis. 13: 254. PMID: 35314669
7. BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway.  |  Jiang, F., et al. 2023. Invest Ophthalmol Vis Sci. 64: 12. PMID: 37043340
8. BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages.  |  Sun, W., et al. 2023. Heliyon. 9: e19934. PMID: 37809369
9. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.  |  Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
10. A human Mad protein acting as a BMP-regulated transcriptional activator.  |  Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
11. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.  |  Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
12. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMP-7 Antibody (4E7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-BMP-7 Antibody (4E7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMP-7 Antibody (4E7) Specifications

Alternate Product Name: BMP-7

Product Clone Name: 4E7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 293-431

Epitope Target: BMP-7

Epitope Species: human

Product Reactivity/Detection: BMP-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 1% glycerol

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for BMP-7 Antibody (4E7): N/A

The preferred BMP-7 antibody is BMP-7 Antibody (6E5D12): sc-517294.