BLVRB Antibody (B-9): sc-373692
- BLVRB Antibody (B-9) is a mouse monoclonal IgG1 κ BLVRB antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-206 representing full length BLVRB of human origin
- BLVRB Antibody (B-9) is recommended for detection of BLVRB of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BLVRB Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BLVRB Antibody (B-9) for WB applications. These reagents are now offered in bundles with BLVRB Antibody (B-9) (see ordering information below).
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BLVRB Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects BLVRB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-BLVRB antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BLVRB protein, also known as biliverdin reductase B, flavin reductase, or NADPH-dependent diaphorase, plays a crucial role in fetal heme metabolism by catalyzing the conversion of biliverdin to bilirubin, a process vital for the detoxification of heme breakdown products. This enzyme is predominantly localized in the cytoplasm and is highly expressed in fetal liver and adult erythrocytes, with lower levels found in the heart, lung, cerebrum, and adrenal gland. BLVRB′s ability to facilitate the reduction of biliverdin is essential for maintaining bilirubin levels, which are important for preventing oxidative stress and ensuring proper cellular function. Additionally, BLVRB contains a single binding site for its substrates and interacts with them primarily through hydrophobic interactions, which is significant for enzymatic activity. Furthermore, BLVRB exhibits ferric reductase activity and serves as a reliable marker for nitric oxide synthase, underscoring its importance in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BLVRB Antibody (B-9) References:
- Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B). | Cunningham, O., et al. 2000. Biochem J. 345 Pt 2: 393-9. PMID: 10620517
- Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites. | Cunningham, O., et al. 2000. J Biol Chem. 275: 19009-17. PMID: 10858451
- Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. | Pereira, PJ., et al. 2001. Nat Struct Biol. 8: 215-20. PMID: 11224564
- Haem degradation in animals and plants. | Mantle, TJ. 2002. Biochem Soc Trans. 30: 630-3. PMID: 12196151
- The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin reductase. | Wang, J. and de Montellano, PR. 2003. J Biol Chem. 278: 20069-76. PMID: 12626517
- Flavin-dependent halogenases involved in secondary metabolism in bacteria. | van Pée, KH. and Patallo, EP. 2006. Appl Microbiol Biotechnol. 70: 631-41. PMID: 16544142
- A common system of sparsely-branched projection (reticular) NADPH-diaphorase neurons in formations of densely-branched cells in the human forebrain. | Leontovich, TA., et al. 2006. Neurosci Behav Physiol. 36: 929-40. PMID: 17024332
- Evidence that biliverdin-IX beta reductase and flavin reductase are identical. | Shalloe, F., et al. 1996. Biochem J. 316 (Pt 2): 385-7. PMID: 8687377
- Molecular cloning and expression of human liver biliverdin-IX beta reductase. | Komuro, A., et al. 1996. Biol Pharm Bull. 19: 796-804. PMID: 8799475
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BLVRB Antibody (B-9) | sc-373692 | 200 µg/ml | $322.00 | |||
BLVRB Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-529539 | 200 µg Ab; 10 µg BP | $361.00 | |||
BLVRB Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-522459 | 200 µg Ab, 40 µg BP | $361.00 | |||
BLVRB Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-543566 | 200 µg Ab; 20 µg BP | $361.00 | |||
BLVRB Antibody (B-9) AC | sc-373692 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BLVRB Antibody (B-9) HRP | sc-373692 HRP | 200 µg/ml | $322.00 | |||
BLVRB Antibody (B-9) FITC | sc-373692 FITC | 200 µg/ml | $336.00 | |||
BLVRB Antibody (B-9) PE | sc-373692 PE | 200 µg/ml | $349.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 488 | sc-373692 AF488 | 200 µg/ml | $364.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 546 | sc-373692 AF546 | 200 µg/ml | $364.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 594 | sc-373692 AF594 | 200 µg/ml | $364.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 647 | sc-373692 AF647 | 200 µg/ml | $364.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 680 | sc-373692 AF680 | 200 µg/ml | $364.00 | |||
BLVRB Antibody (B-9) Alexa Fluor® 790 | sc-373692 AF790 | 200 µg/ml | $364.00 |