BLVRA Antibody (F-1): sc-393385

BLVRA Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BLVRA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BLVRA Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Biliverdin reductase A (BLVRA), also known as biliverdin-IX α-reductase, plays a crucial role in the heme catabolic pathway by reducing biliverdin IX α to bilirubin, a potent antioxidant that protects cells from oxidative stress. This enzymatic conversion is vital for maintaining cellular health, as bilirubin has been shown to have anti-inflammatory and cytoprotective properties. BLVRA is primarily expressed in the liver, where BLVRA contributes to the detoxification of heme, and BLVRA activity is essential for preventing the accumulation of potentially harmful heme breakdown products. The gene encoding BLVRA is located on chromosome 7p14-cen, and BLVRA belongs to the GFO/iIDH/MocA family, highlighting BLVRA′s evolutionary significance.

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BLVRA Antibody (F-1) References:

1. Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes.  |  Bonkovsky, HL., et al. 1990. Eur J Biochem. 189: 155-66. PMID: 2158889
2. Identification of the amino acid residues essential for the activity and the interconversion of the molecular forms of biliverdin reductase.  |  Frydman, J., et al. 1990. Biochim Biophys Acta. 1040: 119-29. PMID: 2378896
3. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.  |  Yamaguchi, T., et al. 1994. J Biol Chem. 269: 24343-8. PMID: 7929092
4. Purification and characterization of human biliverdin reductase.  |  Maines, MD. and Trakshel, GM. 1993. Arch Biochem Biophys. 300: 320-6. PMID: 8424666

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BLVRA Antibody (F-1) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-BLVRA Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BLVRA Antibody (F-1) Specifications

Alternate Product Name: BLVRA

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 75-296

Epitope Target: BLVRA

Epitope Species: human

Product Reactivity/Detection: BLVRA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for BLVRA Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin