Blood Group Wrb Antibody (E6): sc-81763

Blood Group Wrb Antibody (E6) is a mouse monoclonal IgG2b antibody that detects Blood Group Wrb in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Blood Group Wrb is a critical antigen associated with the Wright blood group system, which includes the Wra and Wrb antigens encoded by alleles of the same gene. The Wrb antigen is particularly significant as Blood Group Wrb links to the red blood cell (RBC) band 3 protein and glycophorin A (GPA), both of which play essential roles in maintaining erythrocyte membrane integrity and facilitating cell-cell interactions. The presence of Wrb antigens on erythrocytes and certain epithelial cells is crucial for blood transfusion compatibility and can influence immune responses during transfusions or organ transplants. Additionally, the modulation of Wrb antigens during malignant cellular transformation highlights their potential as biomarkers for cancer diagnosis and treatment monitoring. Blood Group Wrb (E6) monoclonal antibody provides a valuable tool for researchers studying blood group antigens and their implications in health and disease.

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Blood Group Wrb Antibody (E6) References:

1. Biotinylation modifies red cell antigens.  |  Cowley, H., et al. 1999. Transfusion. 39: 163-8. PMID: 10037126
2. Glycophorin A mutation Ala65 --> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wrb expression: direct evidence for GPA/band 3 interaction necessary for normal Wrb expression.  |  Poole, J., et al. 1999. Transfus Med. 9: 167-74. PMID: 10354388
3. An autoantibody with anti-Wrb specificity in a patient with warm autoimmune hemolytic anemia.  |  Goldfinger, D., et al. 1975. Transfusion. 15: 351-2. PMID: 1166507
4. Relationship of the human erythrocyte Wrb antigen to an interaction between glycophorin A and band 3.  |  Telen, MJ. and Chasis, JA. 1990. Blood. 76: 842-8. PMID: 2383660
5. Demonstration of anti-Wrb in a second serum containing anti-Ena.  |  Pavone, BG., et al. 1978. Transfusion. 18: 155-9. PMID: 347644
6. High frequency antigens of human erythrocyte membrane sialoglycoproteins, III. Studies on the EnaFR, Wrb and Wra antigens.  |  Dahr, W., et al. 1986. Biol Chem Hoppe Seyler. 367: 1033-45. PMID: 3539140
7. Selective depression of blood group antigens associated with hereditary ovalocytosis among melanesians.  |  Booth, PB., et al. 1977. Vox Sang. 32: 99-110. PMID: 403680
8. Phospholipid dependence of Wrb antigen expression in human erythrocyte membranes.  |  Rearden, A. 1985. Vox Sang. 49: 346-53. PMID: 4082531
9. Monoclonal antibodies to human erythrocytes.  |  Anstee, DJ. and Edwards, PA. 1982. Eur J Immunol. 12: 228-32. PMID: 6807697
10. The phenotypes En(a-), Wr(a-b-), and En(a+), Wr(a+b-), and further studies on the Wright and En blood group systems.  |  Issitt, PD., et al. 1976. Transfusion. 16: 396-407. PMID: 982531

The preferred WRB antibody is WRB Antibody (G-1): sc-393597.