BICD2 Antibody (E-12): sc-393631
- BICD2 Antibody (E-12) is a mouse monoclonal IgG2b κ BICD2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 154-173 near the N-terminus of BICD2 of human origin
- BICD2 Antibody (E-12) is recommended for detection of BICD2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and porcine
- Anti-BICD2 Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for BICD2 Antibody (E-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with BICD2 Antibody (E-12) (see ordering information below).
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BICD2 Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects BICD2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BICD2 Antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BICD2, also known as bicaudal D homolog 2, plays a crucial role in intracellular transport and is essential for proper functioning of the Golgi apparatus. BICD2 consists of 824 amino acids and is expressed ubiquitously, localizing primarily to the Golgi apparatus, cytoplasm, and cytoskeleton. BICD2 is particularly important for recruiting the dynein-dynactin motor complex, which is vital for transport of vesicles from the Golgi to the endoplasmic reticulum, thereby facilitating efficient cellular communication and protein trafficking. Additionally, BICD2 interacts with Rab 6A on the trans-Golgi network and cytoplasmic vesicles, highlighting BICD2′s role in vesicular transport processes. BICD2 undergoes phosphorylation by NEK9, which can influence BICD2′s function and interactions. BICD2 exists in two isoforms due to alternative splicing and is encoded by a gene located on human chromosome 9, making BICD2 a significant target for studies related to cellular transport mechanisms and their implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BICD2 Antibody (E-12) References:
- Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. | Hoogenraad, CC., et al. 2001. EMBO J. 20: 4041-54. PMID: 11483508
- Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. | Holland, PM., et al. 2002. J Biol Chem. 277: 16229-40. PMID: 11864968
- Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. | Matanis, T., et al. 2002. Nat Cell Biol. 4: 986-92. PMID: 12447383
- Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. | Hoogenraad, CC., et al. 2003. EMBO J. 22: 6004-15. PMID: 14609947
- Assay and properties of rab6 interaction with dynein-dynactin complexes. | Fuchs, E., et al. 2005. Methods Enzymol. 403: 607-18. PMID: 16473624
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | Ishikawa, K., et al. 1998. DNA Res. 5: 169-76. PMID: 9734811
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BICD2 Antibody (E-12) | sc-393631 | 200 µg/ml | $316.00 | |||
BICD2 Antibody (E-12): m-IgG2b BP-HRP Bundle | sc-548780 | 200 µg Ab; 10 µg BP | $354.00 | |||
BICD2 Antibody (E-12) AC | sc-393631 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BICD2 Antibody (E-12) HRP | sc-393631 HRP | 200 µg/ml | $316.00 | |||
BICD2 Antibody (E-12) FITC | sc-393631 FITC | 200 µg/ml | $330.00 | |||
BICD2 Antibody (E-12) PE | sc-393631 PE | 200 µg/ml | $343.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 488 | sc-393631 AF488 | 200 µg/ml | $357.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 546 | sc-393631 AF546 | 200 µg/ml | $357.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 594 | sc-393631 AF594 | 200 µg/ml | $357.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 647 | sc-393631 AF647 | 200 µg/ml | $357.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 680 | sc-393631 AF680 | 200 µg/ml | $357.00 | |||
BICD2 Antibody (E-12) Alexa Fluor® 790 | sc-393631 AF790 | 200 µg/ml | $357.00 | |||
BICD2 (E-12) Neutralizing Peptide | sc-393631 P | 100 µg/0.5 ml | $68.00 |