BICC1 Antibody (A-12): sc-514846
- BICC1 Antibody (A-12) is a mouse monoclonal IgG1 κ BICC1 antibody provided at 200 µg/ml
- raised against amino acids 243-480 mapping within an internal region of BICC1 of human origin
- BICC1 Antibody (A-12) is recommended for detection of BICC1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BICC1 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BICC1 Antibody (A-12) for WB applications. These reagents are now offered in bundles with BICC1 Antibody (A-12) (see ordering information below).
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BICC1 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects BICC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BICC1 (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein belonging to the BICC family and functions as a putative RNA-binding protein that regulates gene expression during embryonic development by modulating protein translation. BICC1 contains two KH domains and one sterile alpha motif (SAM) domain, and exists in two alternatively spliced isoforms, with isoform 1 showing higher expression, particularly in nerve tissue. BICC1 localizes predominantly in the cytoplasm and shows wide expression across various normal tissues, including all brain regions such as the cerebral cortex, hippocampus, and midbrain. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain-dependent manner, suggesting distinct biological functions for different BICC1 isoforms. Genetic variants in the BICC1 gene, which maps to chromosome 10q21.1, have been implicated in recurrent unipolar major depression, highlighting potential relevance in neuropsychiatric disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BICC1 Antibody (A-12) References:
- Report of the third international workshop on human chromosome 10 mapping and sequencing 1999. | Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
- The DNA sequence and comparative analysis of human chromosome 10. | Deloukas, P., et al. 2004. Nature. 429: 375-81. PMID: 15164054
- Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14. | Nonneman, D. and Rohrer, GA. 2004. Anim Genet. 35: 338-43. PMID: 15265077
- Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition. | Wimmers, K., et al. 2007. Anim Genet. 38: 474-84. PMID: 17697135
- Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire. | Chan, IH. and Privalsky, ML. 2009. Oncogene. 28: 4162-74. PMID: 19749797
- Genome-wide association study of major recurrent depression in the U.K. population. | Lewis, CM., et al. 2010. Am J Psychiatry. 167: 949-57. PMID: 20516156
- Overview of the genetics of major depressive disorder. | Lohoff, FW. 2010. Curr Psychiatry Rep. 12: 539-46. PMID: 20848240
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BICC1 Antibody (A-12) | sc-514846 | 200 µg/ml | $322.00 | |||
BICC1 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-531231 | 200 µg Ab; 10 µg BP | $361.00 | |||
BICC1 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-524861 | 200 µg Ab, 40 µg BP | $361.00 | |||
BICC1 Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-544444 | 200 µg Ab; 20 µg BP | $361.00 | |||
BICC1 Antibody (A-12) AC | sc-514846 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BICC1 Antibody (A-12) HRP | sc-514846 HRP | 200 µg/ml | $322.00 | |||
BICC1 Antibody (A-12) FITC | sc-514846 FITC | 200 µg/ml | $336.00 | |||
BICC1 Antibody (A-12) PE | sc-514846 PE | 200 µg/ml | $349.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 488 | sc-514846 AF488 | 200 µg/ml | $364.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 546 | sc-514846 AF546 | 200 µg/ml | $364.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 594 | sc-514846 AF594 | 200 µg/ml | $364.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 647 | sc-514846 AF647 | 200 µg/ml | $364.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 680 | sc-514846 AF680 | 200 µg/ml | $364.00 | |||
BICC1 Antibody (A-12) Alexa Fluor® 790 | sc-514846 AF790 | 200 µg/ml | $364.00 |