beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12): sc-518080

β3-AR Antibody (B-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects β3-AR of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-β3-AR antibody (B-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β3-adrenergic receptor (β3-AR) plays a crucial role in regulating lipolysis and thermogenesis in adipose tissue, making β3-AR essential for energy metabolism and weight management. Located primarily in adipose tissues, heart, and smooth muscle of bladder, colon, small intestine, and stomach, β3-AR is vital for maintaining metabolic homeostasis. Notably, in human corpus cavernosum, β3-AR mediates a vasorelaxant tone linked to inhibition of RhoA/Rho-kinase pathway, highlighting β3-AR′s importance in vascular function. Additionally, β3-AR interacts directly with SH3 domain of Src through proline-rich motifs (PXXP) found in β3-AR′s third intracellular loop and carboxy-terminus, indicating β3-AR′s involvement in intracellular signaling pathways. This multifaceted role of β3-AR underscores β3-AR′s significance in both physiological and pathological processes, making β3-AR monoclonal antibody (B-12) an invaluable tool for researchers studying adrenergic signaling and its implications in various diseases.

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beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12) References:

1. Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery.  |  Pourageaud, F., et al. 2005. Naunyn Schmiedebergs Arch Pharmacol. 372: 14-23. PMID: 16133491
2. Ghrelin affects gastrectomy-induced decrease in UCP1 and beta3-AR mRNA expression in mice.  |  Lindqvist, A., et al. 2007. Regul Pept. 142: 24-8. PMID: 17328973
3. Impact of rosiglitazone on the expression of beta3-AR in the stable cell lines expressed beta3-AR gene.  |  Zhao, X., et al. 2007. Clin Chem Lab Med. 45: 1511-6. PMID: 17970706
4. Association of PPAR-γ2 and β3-AR Polymorphisms With Postmenopausal Hypertension.  |  Grygiel-Górniak, B., et al. 2015. J Clin Hypertens (Greenwich). 17: 549-56. PMID: 25827163
5. Sleep and body temperature in TNFα knockout mice: The effects of sleep deprivation, β3-AR stimulation and exogenous TNFα.  |  Szentirmai, É. and Kapás, L. 2019. Brain Behav Immun. 81: 260-271. PMID: 31220563
6. Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.  |  Liu, P., et al. 2019. Nat Commun. 10: 5070. PMID: 31699980
7. Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.  |  Byun, S., et al. 2022. Proc Natl Acad Sci U S A. 119: e2205626119. PMID: 35737830
8. Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.  |  Kong, L., et al. 2022. Plant Foods Hum Nutr. 77: 529-537. PMID: 35986845
9. Capsaicin induces ATP-dependent thermogenesis via the activation of TRPV1/β3-AR/α1-AR in 3T3-L1 adipocytes and mouse model.  |  Abdillah, AM. and Yun, JW. 2024. Arch Biochem Biophys. 755: 109975. PMID: 38531438
10. Molecular Mechanism of the β3AR Agonist Activity of a β-Blocker.  |  Zheng, S., et al. 2024. Chempluschem. 89: e202400288. PMID: 39046191

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12) Specifications

Alternate Product Name: β3-AR

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 381-408

Epitope Target: β₃-AR

Epitope Species: human

Product Reactivity/Detection: β₃-AR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (B-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred beta 3 Adrenergic Receptor/ADRB3/β3-AR antibody is beta 3 Adrenergic Receptor/ADRB3/β3-AR Antibody (C-5): sc-515763.