Date published: 2026-4-27

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beta3-AR Inhibitors

Santa Cruz Biotechnology now offers a broad range of beta3-AR Inhibitors for use in various applications. Beta3-adrenergic receptor (beta3-AR) inhibitors are essential tools in scientific research, particularly in the study of metabolic regulation, energy balance, and adipose tissue function. Beta3-ARs are G-protein-coupled receptors primarily located in brown and beige adipose tissues, where they play a critical role in regulating thermogenesis, lipolysis, and overall energy expenditure. By inhibiting these receptors, researchers can investigate the pathways involved in fat metabolism and the molecular mechanisms that underlie the storage and utilization of energy. Beta3-AR inhibitors are particularly valuable in studies focused on understanding the role of beta3-AR in the development and function of adipose tissue, as well as its contribution to conditions such as obesity, insulin resistance, and metabolic syndrome. These inhibitors are used to explore the complex interactions between beta3-AR signaling and other metabolic pathways, providing insights into how alterations in this signaling can impact energy homeostasis and metabolic health. Additionally, beta3-AR inhibitors are employed in research aimed at understanding how this receptor influences cardiovascular function, as beta3-AR activity has been linked to vascular tone and heart rate regulation. The availability of a diverse range of beta3-AR inhibitors allows scientists to design experiments tailored to specific aspects of beta3-AR function, advancing our knowledge of metabolic regulation and its implications for health and disease. View detailed information on our available beta3-AR Inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-748,337

244192-94-7sc-204044
sc-204044A
10 mg
50 mg
$258.00
$1068.00
4
(1)

L-748,337 is a selective beta3-adrenergic receptor agonist characterized by its unique binding affinity and specificity. Its molecular structure enables precise interactions with receptor sites, triggering distinct allosteric effects that modulate downstream signaling pathways. The compound exhibits notable reaction kinetics, with a fast association rate and a gradual dissociation, allowing for sustained receptor engagement. Additionally, its lipophilic nature enhances membrane permeability, influencing its bioavailability and interaction with cellular environments.

SR 59230A hydrochloride

1135278-41-9sc-204302
sc-204302A
10 mg
50 mg
$383.00
$1533.00
3
(1)

SR 59230A hydrochloride is a selective beta3-adrenergic receptor antagonist known for its unique ability to disrupt receptor activation. Its structural conformation allows for specific interactions with the receptor's binding site, leading to competitive inhibition of agonist activity. The compound demonstrates a slow onset of action, resulting in prolonged receptor occupancy. Its hydrophilic characteristics influence solubility and distribution, impacting its interaction dynamics within biological systems.

S(−)-Cyanopindolol hemifumarate salt

874882-72-1sc-253460
sc-253460A
1 mg
5 mg
$197.00
$758.00
(0)

S(-)-Cyanopindolol hemifumarate salt exhibits selective binding to beta3-adrenergic receptors, characterized by its unique stereochemistry that enhances receptor affinity. This compound engages in distinct molecular interactions, stabilizing the receptor in an inactive conformation. Its kinetic profile reveals a rapid association and a gradual dissociation, allowing for sustained modulation of receptor activity. Additionally, its amphipathic nature influences membrane permeability and cellular uptake, affecting its overall bioavailability.