beta Synuclein Antibody (8): sc-136452

β-synuclein Antibody (8) is a mouse monoclonal IgG1 kappa light chain antibody that detects β-synuclein in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). anti-β-synuclein antibody (8) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. β-synuclein (8) monoclonal antibody plays a crucial role in studying synaptic function and neuronal plasticity, which are essential for proper cognitive and motor functions. Located predominantly in presynaptic terminals, β-synuclein interacts with other synaptic proteins, contributing to the maintenance of synaptic integrity and neurotransmitter release. β-synuclein expression is particularly important in the context of neurodegenerative diseases, as alterations in synuclein levels can disrupt synaptic homeostasis and lead to neuronal dysfunction. β-synuclein has been shown to modulate the aggregation of α-synuclein, a protein closely associated with Parkinson′s disease, suggesting that understanding β-synuclein function could provide insights into therapeutic strategies for synucleinopathies.

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beta Synuclein Antibody (8) References:

1. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.  |  da Costa, CA., et al. 2003. J Biol Chem. 278: 37330-5. PMID: 12867415
2. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.  |  Wilson, CA., et al. 2004. J Cell Biol. 165: 335-46. PMID: 15123735
3. Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein.  |  Lee, D., et al. 2004. FEBS Lett. 576: 256-60. PMID: 15474047
4. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein.  |  Snyder, H., et al. 2005. J Biol Chem. 280: 7562-9. PMID: 15591046
5. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system.  |  Iwai, A., et al. 1995. Neuron. 14: 467-75. PMID: 7857654
6. Identification of two distinct synucleins from human brain.  |  Jakes, R., et al. 1994. FEBS Lett. 345: 27-32. PMID: 8194594
7. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.  |  Uéda, K., et al. 1993. Proc Natl Acad Sci U S A. 90: 11282-6. PMID: 8248242
8. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.  |  Polymeropoulos, MH., et al. 1997. Science. 276: 2045-7. PMID: 9197268
9. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation.  |  Hashimoto, M., et al. 1997. Biochem Biophys Res Commun. 237: 611-6. PMID: 9299413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-beta Synuclein Antibody (8) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-beta Synuclein Antibody (8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

beta Synuclein Antibody (8) Specifications

Alternate Product Name: β-synuclein

Product Clone Name: 8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 107-118

Epitope Target: β-synuclein

Epitope Species: rat

Product Reactivity/Detection: β-synuclein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for beta Synuclein Antibody (8): B: Biotin

The preferred alpha/beta Synuclein antibody is alpha/beta Synuclein Antibody (Syn 202): sc-32281.