β-glucosidase Antibody (B-6): sc-166407

β-glucosidase Antibody (B-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects β-glucosidase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). β-glucosidase Antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β-glucosidase plays a crucial role in the hydrolysis of β-D-glucosides and β-D-galactosides, primarily in the liver, which is essential for the metabolism of complex carbohydrates and the recycling of cellular components. Deficiencies in β-glucosidase activity lead to the accumulation of glucosylceramide, resulting in Gaucher disease, a genetic disorder that significantly impacts the reticuloendothelial system and can lead to severe health complications. β-glucosidase is also vital in the absorption of dietary flavonoid glycosides, as β-glucosidase facilitates a necessary deglycosylation step in the intestinal epithelium, highlighting β-glucosidase′s importance in both metabolic processes and therapeutic applications, particularly in enzyme replacement therapies for Gaucher disease.

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β-glucosidase Antibody (B-6) References:

1. Cloning and characterization of human liver cytosolic beta-glycosidase.  |  de Graaf, M., et al. 2001. Biochem J. 356: 907-10. PMID: 11389701
2. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.  |  Németh, K., et al. 2003. Eur J Nutr. 42: 29-42. PMID: 12594539
3. Paenibacillus sp. TS12 glucosylceramidase: kinetic studies of a novel sub-family of family 3 glycosidases and identification of the catalytic residues.  |  Paal, K., et al. 2004. Biochem J. 378: 141-9. PMID: 14561218
4. Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae.  |  Zhao, L., et al. 2003. Biochemistry. 42: 14794-804. PMID: 14674753
5. Glucosylceramidase mass and subcellular localization are modulated by cholesterol in Niemann-Pick disease type C.  |  Salvioli, R., et al. 2004. J Biol Chem. 279: 17674-80. PMID: 14757764
6. Effect of xylitol on salivary β-glucosidase in humans.  |  Teixeira Essenfelder, L., et al. 2019. Eur J Oral Sci. 127: 472-475. PMID: 31361368
7. Immobilization of β-glucosidase by self-catalysis and compared to crosslinking with glutaraldehyde.  |  Naseer, S., et al. 2020. Int J Biol Macromol. 154: 1490-1495. PMID: 31733256
8. Salivary β-glucosidase as a direct factor influencing the occurrence of halitosis.  |  Teixeira Essenfelder, L., et al. 2021. Biochem Biophys Rep. 26: 100965. PMID: 33732903
9. Adsorption and immobilization of β-glucosidase from Thermoascus aurantiacus on macroporous cryogel by hydrophobic interaction.  |  Mól, PCG., et al. 2023. Prep Biochem Biotechnol. 53: 297-307. PMID: 35671239
10. Improving the cellobiose hydrolysis activity of glucose-stimulating β-glucosidase Bgl2A.  |  Liu, S., et al. 2023. Enzyme Microb Technol. 169: 110289. PMID: 37473697
11. Estrone beta-glucosidase activity in human placenta.  |  Labow, RS., et al. 1980. Can J Biochem. 58: 23-9. PMID: 7388673
12. Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase.  |  Overkleeft, HS., et al. 1998. J Biol Chem. 273: 26522-7. PMID: 9756888

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-glucosidase Antibody (B-6) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-β-glucosidase Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-glucosidase Antibody (B-6) Specifications

Alternate Product Name: Beta glucosidase

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 237-536

Epitope Target: β-glucosidase

Epitope Species: human

Product Reactivity/Detection: β-glucosidase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for β-glucosidase Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin