β-dystroglycan Antibody (B-4): sc-165997

β-dystroglycan Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects β-dystroglycan in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-dystroglycan plays a crucial role in forming the dystrophin-associated protein complex, which maintains the structural integrity of muscle cells. This complex links the cytoskeleton to the extracellular matrix, providing mechanical stability during muscle contraction. β-dystroglycan′s interaction with dystrophin is particularly important in skeletal and cardiac muscle, helping prevent muscle damage during physical activity. β-dystroglycan′s involvement in clustering nicotinic acetylcholine receptors at the neuromuscular junction underscores its significance in neuromuscular transmission and overall muscle function. With its ability to facilitate these critical interactions, β-dystroglycan (B-4) antibody serves as an invaluable tool for researchers studying muscle-related diseases and cellular mechanisms.

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β-dystroglycan Antibody (B-4) References:

1. Dystrophin and beta-dystroglycan in photoreceptor terminals from normal and mdx3Cv mouse retinae.  |  Blank, M., et al. 1999. Eur J Neurosci. 11: 2121-33. PMID: 10336681
2. Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.  |  Huang, X., et al. 2000. Nat Struct Biol. 7: 634-8. PMID: 10932245
3. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.  |  Sotgia, F., et al. 2001. Biochemistry. 40: 14585-92. PMID: 11724572
4. Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan.  |  Kunz, S., et al. 2003. Virology. 316: 213-20. PMID: 14644604
5. Effect of beta-dystroglycan processing on utrophin/Dp116 anchorage in normal and mdx mouse Schwann cell membrane.  |  Hnia, K., et al. 2006. Neuroscience. 141: 607-620. PMID: 16735092
6. Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.  |  Ilarraza-Lomeli, R., et al. 2007. Neuroreport. 18: 1657-61. PMID: 17921863
7. Expression of beta-dystroglycan is reduced or absent in many human carcinomas.  |  Cross, SS., et al. 2008. Histopathology. 53: 561-6. PMID: 18983465
8. MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.  |  Zhao, XL., et al. 2010. Biochem Biophys Res Commun. 392: 551-6. PMID: 20097170
9. The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity.  |  Azuara-Medina, PM., et al. 2019. Cell Death Dis. 10: 196. PMID: 30814495
10. Dystrophin, utrophin and beta-dystroglycan expression in skeletal muscle from patients with Becker muscular dystrophy.  |  Kawajiri, M., et al. 1996. J Neuropathol Exp Neurol. 55: 896-903. PMID: 8759779

The preferred β-dystroglycan antibody is β-dystroglycan Antibody (4F7): sc-33702.