beta-catenin Antibody (G-10): sc-376959

β-catenin Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect β-catenin, also known as CTNNB1, a crucial protein located primarily at the cell membrane within adherens junctions, as well as in the cytoplasm and nucleus. β-catenin plays a vital role in maintaining cellular adhesion by binding to the intracellular cytoplasmic tail of cadherins, such as E-cadherin, which is essential for preserving tissue architecture and integrity. Beyond structural functions, β-catenin is a key mediator of the Wnt signaling pathway, where nuclear translocation regulates gene transcription involved in cell proliferation, differentiation, and migration, all processes fundamental for normal development and often disrupted in cancer. anti-β-catenin antibody (G-10) specifically targets an epitope between amino acids 755-781 at the C-terminus of human β-catenin, ensuring precise and reliable detection across multiple species, including mouse, rat, human, and avian, as well as additional species such as equine, canine, bovine, and porcine. β-catenin monoclonal antibody (G-10) is validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), making this reagent versatile for diverse research needs. β-catenin (G-10) antibody enables detailed study of roles in both cell adhesion and signaling pathways, serving as an indispensable tool for researchers investigating molecular mechanisms underlying cellular communication, development, and oncogenesis. anti-β-catenin antibody (G-10) demonstrates high specificity and broad applicability, ensuring reliable performance in various experimental setups and facilitating advancements in understanding β-catenin′s functions in numerous biological contexts.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.