beta-catenin Antibody (E-11): sc-133238

β-catenin Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody specifically raised against amino acids 680-781 at the C-terminus of human β-catenin, with confirmed reactivity to mouse, rat, and human β-catenin in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β-catenin, also referred to as CTNNB1, is a multifunctional protein crucial in cellular adhesion and signaling pathways, playing a dual role in cadherin-mediated cell adhesion and Wnt signaling. Within the cell, β-catenin is primarily localized to the cytoplasm and at cell junctions, where β-catenin associates with the intracellular domain of E-cadherin to stabilize cell-cell adhesion. This localization is vital for maintaining tissue integrity and enabling dynamic cellular processes such as migration and morphogenesis. Additionally, β-catenin translocates to the nucleus during Wnt signaling, where β-catenin functions as a transcriptional coactivator for genes involved in proliferation and differentiation, highlighting β-catenin′s role in development and cancer biology. β-catenin also forms complexes with the tumor suppressor protein APC, linking β-catenin to pathways regulating cell growth and tumorigenesis. Anti-β-catenin antibody (E-11) is recommended for researchers studying β-catenin′s critical roles in adhesion, signaling, and disease.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.