β-casein Antibody (H-7): sc-166520
- β-casein Antibody (H-7) is a mouse monoclonal IgG3 κ, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 101-115 within an internal region of β-casein of mouse origin
- recommended for detection of β-casein of mouse origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for β-casein Antibody (H-7). This work is in progress.
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β-casein Antibody (H-7) is a mouse monoclonal IgG3 antibody that detects β-casein in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-casein plays a vital role in the nutritional development of newborn mammals, as β-casein is one of the primary proteins found in mammalian milk, particularly in human milk where β-casein exists alongside k-casein. The unique structure of β-casein, characterized by highly phosphorylated sites, is crucial for calcium-binding capacity, which enhances the digestibility of casein micelles in neonates, especially during the early days of life when colostrum is consumed. The β-casein gene (Bca) is intricately regulated by a network of transcription factors, including Stat5 and C/EBPβ, which respond to lactogenic hormones such as prolactin, insulin, and hydrocortisone, ensuring that β-casein is produced in adequate amounts to support the growth and development of the young. Additionally, the presence of NFκB as a negative regulator during pregnancy highlights the complex interplay of signaling pathways that govern β-casein expression, making β-casein a critical focus for studies related to lactation and neonatal nutrition. Anti-β-casein antibody (H-7) is an essential tool for researchers investigating the roles of milk proteins in health and development.
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β-casein Antibody (H-7) References:
- Health implications of milk containing beta-casein with the A2 genetic variant. | Bell, SJ., et al. 2006. Crit Rev Food Sci Nutr. 46: 93-100. PMID: 16403684
- Polymorphism of bovine beta-casein and its potential effect on human health. | Kamiński, S., et al. 2007. J Appl Genet. 48: 189-98. PMID: 17666771
- Self-assembly of beta-casein and lysozyme. | Pan, X., et al. 2007. J Colloid Interface Sci. 316: 405-12. PMID: 17915243
- Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein. | Brooke-Taylor, S., et al. 2017. Adv Nutr. 8: 739-748. PMID: 28916574
- A comparison of β-casein complexes and micelles as vehicles for trans-/cis-resveratrol. | Cheng, H., et al. 2020. Food Chem. 330: 127209. PMID: 32535314
- Study on β-Casein Depleted Casein Micelles: Micellar Stability, Enzymatic Cross-Linking, and Suitability as Nanocarriers. | Duerasch, A., et al. 2020. J Agric Food Chem. 68: 13940-13949. PMID: 33200608
- Nanosecond structural dynamics of intrinsically disordered β-casein micelles by neutron spectroscopy. | Nakagawa, H., et al. 2021. Biophys J. 120: 5408-5420. PMID: 34717964
- Properties of sodium caseinate as affected by the β-casein phenotypes. | Daniloski, D., et al. 2022. J Colloid Interface Sci. 626: 939-950. PMID: 35835044
- Difficulties in Establishing the Adverse Effects of β-Casomorphin-7 Released from β-Casein Variants-A Review. | de Vasconcelos, ML., et al. 2023. Foods. 12: PMID: 37685085
- Plasmin cleaves human beta-casein. | Greenberg, R. and Groves, ML. 1984. Biochem Biophys Res Commun. 125: 463-8. PMID: 6240266
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-casein Antibody (H-7) | sc-166520 | 200 µg/ml | $322.00 | |||
β-casein (H-7) Neutralizing Peptide | sc-166520 P | 100 µg/0.5 ml | $69.00 |