beta Arrestin 1/2 Antibody (A-1): sc-74591
- beta Arrestin 1/2 Antibody (A-1) is a mouse monoclonal IgG2a κ beta Arrestin 1/2 antibody, cited in 18 publications, provided at 200 µg/ml
- raised against amino acids 7-290 mapping near the N-terminus of β-Arrestin-1 of human origin
- beta Arrestin 1/2 Antibody (A-1) is recommended for detection of β-Arrestin-1 and β-Arrestin-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including porcine
- Anti-beta Arrestin 1/2 Antibody (A-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for beta Arrestin 1/2 Antibody (A-1) for WB and IHC(P) applications. This reagent is now offered in a bundle with beta Arrestin 1/2 Antibody (A-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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β-Arrestin-1/2 Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect both β-Arrestin-1 and β-Arrestin-2 across multiple species including mouse, rat, human, bovine, and porcine. β-Arrestin-1/2 monoclonal antibody (A-1) is raised against amino acids 7-290 near the N-terminus of the human β-Arrestin-1 protein, ensuring reliable detection in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β-Arrestin-1 and β-Arrestin-2 are pivotal regulators of G protein-coupled receptor (GPCR) signaling, mediating receptor desensitization, internalization, and initiating alternative signaling pathways independent of G proteins. Structurally, both proteins consist of two distinct domains, the N-terminal domain and the C-terminal domain, which form a bilobal structure essential for their interaction with phosphorylated GPCRs and various signaling proteins. Post-translational modifications, such as phosphorylation and ubiquitination, play a significant role in modulating the functionality of β-Arrestins by regulating their interactions, stability, and localization within the cell. β-Arrestin-1 and β-Arrestin-2 interact with specific proteins including G protein-coupled receptor kinases (GRKs), clathrin, and the AP-2 adaptor complex, which are vital for receptor internalization and the formation of signaling complexes. These interactions are crucial for maintaining precise control over cellular responses to hormones, neurotransmitters, and sensory stimuli, thereby influencing processes such as hormone signaling, neurotransmission, and immune responses. Predominantly expressed in spleen and neuronal tissues, β-Arrestin-1 and β-Arrestin-2 are integral to maintaining cellular homeostasis and facilitating appropriate responses to extracellular stimuli. Anti-β-Arrestin-1/2 antibody (A-1) is recommended for researchers studying the structural and functional dynamics of β-Arrestin-mediated signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
beta Arrestin 1/2 Antibody (A-1) | sc-74591 | 200 µg/ml | $322.00 | |||
beta Arrestin 1/2 Antibody (A-1): m-IgGκ BP-HRP Bundle | sc-521151 | 200 µg Ab, 40 µg BP | $361.00 | |||
beta Arrestin 1/2 Antibody (A-1) AC | sc-74591 AC | 500 µg/ml, 25% agarose | $424.00 | |||
beta Arrestin 1/2 Antibody (A-1) HRP | sc-74591 HRP | 200 µg/ml | $322.00 | |||
beta Arrestin 1/2 Antibody (A-1) FITC | sc-74591 FITC | 200 µg/ml | $336.00 | |||
beta Arrestin 1/2 Antibody (A-1) PE | sc-74591 PE | 200 µg/ml | $349.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 488 | sc-74591 AF488 | 200 µg/ml | $364.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 546 | sc-74591 AF546 | 200 µg/ml | $364.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 594 | sc-74591 AF594 | 200 µg/ml | $364.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 647 | sc-74591 AF647 | 200 µg/ml | $364.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 680 | sc-74591 AF680 | 200 µg/ml | $364.00 | |||
beta Arrestin 1/2 Antibody (A-1) Alexa Fluor® 790 | sc-74591 AF790 | 200 µg/ml | $364.00 |