BDP1 Antibody (B-6): sc-515058
- BDP1 Antibody (B-6) is a mouse monoclonal IgG1 λ BDP1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 241-453 mapping at the C-terminus of BDP1 of mouse origin
- BDP1 Antibody (B-6) is recommended for detection of BDP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BDP1 Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for BDP1 Antibody (B-6) for WB applications. This reagent is now offered in a bundle with BDP1 Antibody (B-6) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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BDP1 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects BDP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BDP1 Antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BDP1, also known as brain-derived phosphatase 1, plays a crucial role in cellular signaling by regulating protein tyrosine phosphorylation, which is essential for processes such as cell growth, migration, and differentiation. This regulation is achieved through the balance of protein tyrosine kinases and protein tyrosine phosphatases, with BDP1 specifically acting to dephosphorylate key tyrosine kinases like Src and EGFR that are often overexpressed in various tumor tissues. While BDP1 is predominantly studied in the context of the brain, BDP1 expression is also found in the colon and several tumor-derived cell lines, highlighting BDP1′s potential relevance in both normal physiology and cancer biology. BDP1′s ability to modulate kinase activity underscores BDP1′s importance in maintaining cellular homeostasis and potential as a therapeutic target in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BDP1 Antibody (B-6) References:
- The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. | Lowenstein, EJ., et al. 1992. Cell. 70: 431-42. PMID: 1322798
- Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. | Gensler, M., et al. 2004. J Biol Chem. 279: 12110-6. PMID: 14660651
- A bioinformatics analysis of protein tyrosine phosphatases in humans. | Gandhi, TK., et al. 2005. DNA Res. 12: 79-89. PMID: 16303740
- Identification of candidates for tumor-specific alternative splicing in the thyroid. | Guimarães, GS., et al. 2006. Genes Chromosomes Cancer. 45: 540-53. PMID: 16493598
- Structural basis of RNA polymerase III transcription initiation. | Abascal-Palacios, G., et al. 2018. Nature. 553: 301-306. PMID: 29345637
- Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity. | Herrera, MC., et al. 2018. Nucleic Acids Res. 46: 11698-11711. PMID: 30247619
- Protein tyrosine phosphatases. | Walton, KM. and Dixon, JE. 1993. Annu Rev Biochem. 62: 101-20. PMID: 8352585
- Characterization of the PEST family protein tyrosine phosphatase BDP1. | Kim, YW., et al. 1996. Oncogene. 13: 2275-9. PMID: 8950995
- Genetic analysis of protein tyrosine phosphatases. | Van Vactor, D., et al. 1998. Curr Opin Genet Dev. 8: 112-26. PMID: 9529614
- Antigen receptor signaling: integration of protein tyrosine kinase functions. | Tamir, I. and Cambier, JC. 1998. Oncogene. 17: 1353-64. PMID: 9779983
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BDP1 Antibody (B-6) | sc-515058 | 200 µg/ml | $316.00 | |||
BDP1 Antibody (B-6): m-IgGλ BP-HRP Bundle | sc-524919 | 200 µg Ab, 40 µg BP | $354.00 | |||
BDP1 Antibody (B-6) AC | sc-515058 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BDP1 Antibody (B-6) HRP | sc-515058 HRP | 200 µg/ml | $316.00 | |||
BDP1 Antibody (B-6) FITC | sc-515058 FITC | 200 µg/ml | $330.00 | |||
BDP1 Antibody (B-6) PE | sc-515058 PE | 200 µg/ml | $343.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 488 | sc-515058 AF488 | 200 µg/ml | $357.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 546 | sc-515058 AF546 | 200 µg/ml | $357.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 594 | sc-515058 AF594 | 200 µg/ml | $357.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 647 | sc-515058 AF647 | 200 µg/ml | $357.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 680 | sc-515058 AF680 | 200 µg/ml | $357.00 | |||
BDP1 Antibody (B-6) Alexa Fluor® 790 | sc-515058 AF790 | 200 µg/ml | $357.00 |