BDH1 Antibody (6-RY34): sc-134281

BDH1 Antibody (6-RY34) is a mouse monoclonal IgG2a antibody that detects BDH1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). BDH1, also known as 3-hydroxybutyrate dehydrogenase, type 1, is a 343 amino acid protein that resides in the mitochondrial matrix and is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH1 exists as a homotetramer and plays a crucial role in the metabolic degradation of fatty acids by catalyzing the NAD+-dependent interconversion of (R)-3-hydroxybutanoate and acetoacetate, a reaction that is allosterically activated by phosphatidylcholine. BDH1 is involved in the production of ketone bodies, which are vital energy sources during periods of fasting or prolonged exercise. The gene encoding BDH1 is located on human chromosome 3, a region that contains over 1,100 genes, including those associated with various human cancers and a chemokine receptor gene cluster, highlighting the potential implications of BDH1 in metabolic disorders and cancer biology. Anti-BDH1 antibody (6-RY34) is an essential tool for researchers investigating the metabolic pathways involving ketone bodies and their broader implications in health and disease.

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BDH1 Antibody (6-RY34) References:

1. E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.  |  Major, JL., et al. 2017. PLoS One. 12: e0170066. PMID: 28085920
2. Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.  |  Otsuka, H., et al. 2020. J Inherit Metab Dis. 43: 960-968. PMID: 32279332
3. MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells.  |  Zhang, H., et al. 2021. Signal Transduct Target Ther. 6: 135. PMID: 33795651
4. Anti-Tumor Effects of BDH1 in Acute Myeloid Leukemia.  |  Han, F., et al. 2021. Front Oncol. 11: 694594. PMID: 34150668
5. Expression and clinical significance of BDH1 in liver cancer.  |  Liu, Z., et al. 2021. Medicine (Baltimore). 100: e28013. PMID: 35049211
6. BDH1 promotes lung cancer cell proliferation and metastases by PARP1-mediated autophagy.  |  Zhang, Z., et al. 2023. J Cell Mol Med. 27: 939-949. PMID: 36919822
7. Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer's disease.  |  Zhang, Y., et al. 2023. J Transl Med. 21: 458. PMID: 37434203
8. BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway.  |  Wan, SR., et al. 2023. Aging (Albany NY). 15: 13384-13410. PMID: 38015723
9. BDH1-mediated LRRC31 regulation dependent on histone lysine β-hydroxybutyrylation to promote lung adenocarcinoma progression.  |  Huang, J., et al. 2023. MedComm (2020). 4: e449. PMID: 38098610
10. Empagliflozin improves mitochondrial dysfunction in diabetic cardiomyopathy by modulating ketone body metabolism and oxidative stress.  |  Cai, W., et al. 2024. Redox Biol. 69: 103010. PMID: 38160540
11. Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding.  |  Williams, AS., et al. 2024. Cell Metab. 36: 422-437.e8. PMID: 38325337
12. SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation.  |  Liu, W., et al. 2024. Cell Metab. 36: 2245-2261.e6. PMID: 39243758

The preferred BDH1 antibody is BDH1 Antibody (G-5): sc-514413.