BCoR Antibody (C-10): sc-514576

BCoR Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects BCoR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BCoR antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BCoR, or BCL-6 corepressor, is a crucial 1,755 amino acid protein that plays a significant role in transcriptional repression by associating with histone deacetylases (HDACs) to inhibit the activity of Bcl-6, a transcriptional repressor involved in regulating apoptosis and immune responses. BCoR is predominantly localized in the nucleus, where BCoR interacts with other proteins through three ankyrin repeat domains, facilitating function in gene regulation. Mutations in the BCoR gene can lead to microphthalmia with associated anomalies 2, a condition characterized by a range of developmental issues, including renal aplasia and mental retardation. BCoR is expressed ubiquitously across various tissues, and four isoforms, produced through alternative splicing, contribute to diverse regulatory roles in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BCoR Antibody (C-10) References:

1. BCoR, a novel corepressor involved in BCL-6 repression.  |  Huynh, KD., et al. 2000. Genes Dev. 14: 1810-23. PMID: 10898795
2. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR.  |  Ng, D., et al. 2004. Nat Genet. 36: 411-6. PMID: 15004558
3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.  |  Gearhart, MD., et al. 2006. Mol Cell Biol. 26: 6880-9. PMID: 16943429
4. A two base pair deletion in the PQBP1 gene is associated with microphthalmia, microcephaly, and mental retardation.  |  Martínez-Garay, I., et al. 2007. Eur J Hum Genet. 15: 29-34. PMID: 17033686
5. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.  |  Sánchez, C., et al. 2007. Mol Cell Proteomics. 6: 820-34. PMID: 17296600
6. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.  |  Ghetu, AF., et al. 2008. Mol Cell. 29: 384-91. PMID: 18280243
7. Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development.  |  Wamstad, JA., et al. 2008. PLoS One. 3: e2814. PMID: 18795143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BCoR Antibody (C-10) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-BCoR Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BCoR Antibody (C-10) Specifications

Alternate Product Name: BCoR

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: BCoR

Epitope Species: human

Product Reactivity/Detection: BCoR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for BCoR Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin