Bcl10 Antibody (H-2): sc-55511

Bcl10 Antibody (H-2) is a mouse monoclonal IgG2b antibody that detects Bcl10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bcl10, also known as CIPER, c-CARMEN, and mE10, plays a crucial role in regulating apoptosis and immune responses, primarily through involvement in the NFκB signaling pathway. Bcl10 is located in the cytoplasm and is essential for NFκB activation, a key transcription factor regulating genes involved in inflammation, immunity, and cell survival. Cytoplasmic localization of Bcl10 enables interaction with other signaling molecules, facilitating multiprotein complex assembly that leads to downstream signaling pathway activation. The N-terminal caspase recruitment domain (CARD) of Bcl10 is vital for function, mediating oligomerization and subsequent activation of caspase-9, further linking Bcl10 to apoptotic processes. Understanding Bcl10 localization and function is critical, as dysregulation has been implicated in various lymphomas and other malignancies, highlighting potential as a therapeutic target. Anti-Bcl10 antibody (H-2) serves as an invaluable tool for researchers studying intricate mechanisms of cell signaling and apoptosis in health and disease.

The preferred Bcl10 antibody is Bcl10 Antibody (331.3): sc-5273.