Bcl10 Antibody (4F8E8H8): sc-32808

Bcl10 Antibody (4F8E8H8) is a mouse monoclonal IgG1 antibody that detects Bcl10 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Bcl10, also known as CIPER, c-CARMEN, and mE10, plays a crucial role in the regulation of apoptosis and immune responses, primarily through involvement in the NFκB signaling pathway. Bcl10 is located in the cytoplasm and is essential for the activation of NFκB, a key transcription factor that regulates genes involved in inflammation, immunity, and cell survival. Bcl10′s presence in the cytoplasm allows interaction with other signaling molecules, facilitating the assembly of multi-protein complexes vital for the transduction of apoptotic signals. Notably, Bcl10 contains an N-terminal caspase recruitment domain (CARD), which is critical for function, as CARD mediates oligomerization and subsequent activation of downstream signaling pathways. Understanding Bcl10′s role in these processes is important, as dysregulation has been implicated in various lymphomas and other malignancies, highlighting potential as a therapeutic target. Anti-Bcl10 antibody (4F8E8H8) is an invaluable tool for researchers studying apoptosis, immune signaling, and the molecular mechanisms underlying tumorigenesis.

The preferred Bcl10 antibody is Bcl10 Antibody (331.3): sc-5273.