Bcl-2 Antibody (7): sc-130308

Bcl-2 Antibody (7) is a mouse monoclonal IgG2a antibody that detects Bcl-2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Bcl-2 is a crucial anti-apoptotic protein that plays a significant role in regulating apoptosis, which is vital for maintaining tissue homeostasis and protecting against diseases, including cancer. Located primarily in the outer mitochondrial membrane, Bcl-2′s strategic positioning allows direct inhibition of pro-apoptotic factor release, such as cytochrome c, thereby preventing activation of apoptotic pathways. This localization enables Bcl-2 to interact with other members of the Bcl-2 family, including both pro-apoptotic and anti-apoptotic proteins, to maintain a delicate balance between cell survival and death. Dysregulation of Bcl-2 expression or function can lead to uncontrolled cell proliferation and contribute to the development of various malignancies, making Bcl-2 a critical target for therapeutic intervention. Anti-Bcl-2 antibody (7) serves as an invaluable tool for researchers studying apoptosis and cancer biology, providing insights into the mechanisms of cell survival and death.

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.