Bcl-2 Antibody (12): sc-130307

Bcl-2 Antibody (12) is a mouse monoclonal IgG2a antibody that detects Bcl-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Bcl-2 is a crucial anti-apoptotic protein that plays a significant role in regulating apoptosis, which is vital for maintaining tissue homeostasis and protecting against diseases, including cancer. Located primarily in the outer mitochondrial membrane, anti-Bcl-2 antibody (12) targets a protein whose strategic positioning allows effective inhibition of pro-apoptotic factor release, thereby preventing cell death. This localization is essential because Bcl-2 interacts with other members of the Bcl-2 family, such as Bax and Bak, which are key players in the apoptotic pathway. By stabilizing the mitochondrial membrane, Bcl-2 not only promotes cell survival but also contributes to the overall balance between cell death and proliferation, a process that, when disrupted, can lead to tumorigenesis. Bcl-2 monoclonal antibody (12) serves as an invaluable tool for researchers studying the mechanisms of apoptosis and the implications of Bcl-2 in various diseases, particularly in understanding how dysregulation can lead to cancer progression.

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.